Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση

Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called "angiogenic diseases" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the synthesis of basement membrane (b.m.) for the formation of new blood vessels. One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative marker of angiogenesis and for the evaluation of angiogenic and anti-angiogenic factors that may have therapeutic potential.

Grantor dc:publisher

University of Patras

Year dc:date

1991

Authors dc:creator

• Sarmonika, Marianthi
• Σαρμονίκα, Μαριάνθη

• Αγγειογένεση
• Αναστολή της αγγειογένεσης
• Βασική μεμβράνη
• Δημιουργία νέων αγγείων
• Επαγωγή της αγγειογένεσης
• Κολλαγόνο τύπου IV
• Ρυθμός βιοσύνθεσης κολλογονούχων πρωτεϊνών
• Angiogenesis
• Basement membrane
• Collagen type IV
• Formation of new vessels
• Induction of angiogenesis
• Rate of biosynthetic of collagenious proteins
• Φυσικές Επιστήμες
• Βιολογία
• Ιατρική και Επιστήμες Υγείας
• Επιστήμες Υγείας
• Natural Sciences
• Biological Sciences
• Medical and Health Sciences
• Health Sciences

Language dc:language

gre

Identifier

10.12681/eadd/1729

OAI identifier oai:identifier

oai:10442/1729