{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1729"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1729","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση","abstract":"Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called \"angiogenic diseases\" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the synthesis of basement membrane (b.m.) for the formation of new blood vessels. One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative marker of angiogenesis and for the evaluation of angiogenic and anti-angiogenic factors that may have therapeutic potential.","abstract_html":"Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called "angiogenic diseases" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the synthesis of basement membrane (b.m.) for the formation of new blood vessels. One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative marker of angiogenesis and for the evaluation of angiogenic and anti-angiogenic factors that may have therapeutic potential.","abstract_has_math":false,"creators":["Sarmonika, Marianthi","Σαρμονίκα, Μαριάνθη"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1991,"date_issued":"1991","date_published":"1991","updated_at":"2026-07-24T02:25:05Z","subjects":["Αγγειογένεση","Αναστολή της αγγειογένεσης","Βασική μεμβράνη","Δημιουργία νέων αγγείων","Επαγωγή της αγγειογένεσης","Κολλαγόνο τύπου IV","Ρυθμός βιοσύνθεσης κολλογονούχων πρωτεϊνών","Angiogenesis","Basement membrane","Collagen type IV","Formation of new vessels","Induction of angiogenesis","Rate of biosynthetic of collagenious proteins","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1729"],"render_values":[{"text":"10.12681/eadd/1729","href":"https://doi.org/10.12681/eadd/1729","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1729","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Sarmonika, Marianthi","Σαρμονίκα, Μαριάνθη"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1991"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Αγγειογένεση","Αναστολή της αγγειογένεσης","Βασική μεμβράνη","Δημιουργία νέων αγγείων","Επαγωγή της αγγειογένεσης","Κολλαγόνο τύπου IV","Ρυθμός βιοσύνθεσης κολλογονούχων πρωτεϊνών","Angiogenesis","Basement membrane","Collagen type IV","Formation of new vessels","Induction of angiogenesis","Rate of biosynthetic of collagenious proteins","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1729","http://hdl.handle.net/10442/hedi/1729"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called \"angiogenic diseases\" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the synthesis of basement membrane (b.m.) for the formation of new blood vessels. One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative marker of angiogenesis and for the evaluation of angiogenic and anti-angiogenic factors that may have therapeutic potential.","Η αγγειογένεση αποτελεί καθοριστική παράμετρο διάγνωσης ή θεραπευτικής παρέμβασης στις \"αγγειογενετικές ασθένειες\" π.χ. διαβητική αμφιβληστροειδοπάθεια, χρόνια φλεγμονή. Προτείνεται μια βιοχημική μέθοδος αξιολόγησης της αγγειογένεσης που βασίζεται στο γεγονός ότι κατά τα τελευταία στάδια της αγγειογένεσης απαιτείται η σύνθεση βασικής μεμβράνης (β.μ.) για την ολοκλήρωση του σχηματισμού νέων αγγείων. Ένα από τα βασικά συστατικά της β.μ. είναι το κολλαγόνο τύπου IV το οποίο βρίσκεται αποκλειστικά στη β.μ. Συνεπώς υπάρχει άμεσος συσχετισμός μεταξύ της βιοσύνθεσης του κολλαγόνου τύπου IV και κατ' επέκταση της β.μ. με την αγγειογένεση. Επομένως ο βιοχημικός προσδιορισμός της βιοσύνθεσης κολλαγόνου τύπου IV μπορεί να χρησιμοποιηθεί ως ποσοτικός δείκτης της αγγειογένεσης και για την αξιολόγηση αγγειογενετικών και αντι-αγγειογενετικών παραγόντων που θα μπορούν να έχουν θεραπευτικές δυνατότητες."]},{"key":"dc:title","label":"Title","values":["Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση","The correlation of the biosynthesis of basement membrane with angiogenesis"]}]}],"canonical_facts":{"dc:creator":["Sarmonika, Marianthi","Σαρμονίκα, Μαριάνθη"],"dc:date":["1991"],"dc:description":["Angiogenesis is an important determinant for the diagnosis or the therapeutic intervention in the so called \"angiogenic diseases\" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the synthesis of basement membrane (b.m.) for the formation of new blood vessels. One of the basic structural elements of b.m. is collagen type IV which is found only in b.m. therefore there is a correlation between the biosynthesis of collagen type IV and so that of b.m. with angiogenesis. So the evaluation of the biosynthesis of collagen type IV can be used as a quantitative marker of angiogenesis and for the evaluation of angiogenic and anti-angiogenic factors that may have therapeutic potential.","Η αγγειογένεση αποτελεί καθοριστική παράμετρο διάγνωσης ή θεραπευτικής παρέμβασης στις \"αγγειογενετικές ασθένειες\" π.χ. διαβητική αμφιβληστροειδοπάθεια, χρόνια φλεγμονή. Προτείνεται μια βιοχημική μέθοδος αξιολόγησης της αγγειογένεσης που βασίζεται στο γεγονός ότι κατά τα τελευταία στάδια της αγγειογένεσης απαιτείται η σύνθεση βασικής μεμβράνης (β.μ.) για την ολοκλήρωση του σχηματισμού νέων αγγείων. Ένα από τα βασικά συστατικά της β.μ. είναι το κολλαγόνο τύπου IV το οποίο βρίσκεται αποκλειστικά στη β.μ. Συνεπώς υπάρχει άμεσος συσχετισμός μεταξύ της βιοσύνθεσης του κολλαγόνου τύπου IV και κατ' επέκταση της β.μ. με την αγγειογένεση. Επομένως ο βιοχημικός προσδιορισμός της βιοσύνθεσης κολλαγόνου τύπου IV μπορεί να χρησιμοποιηθεί ως ποσοτικός δείκτης της αγγειογένεσης και για την αξιολόγηση αγγειογενετικών και αντι-αγγειογενετικών παραγόντων που θα μπορούν να έχουν θεραπευτικές δυνατότητες."],"dc:identifier":["10.12681/eadd/1729","http://hdl.handle.net/10442/hedi/1729"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["Αγγειογένεση","Αναστολή της αγγειογένεσης","Βασική μεμβράνη","Δημιουργία νέων αγγείων","Επαγωγή της αγγειογένεσης","Κολλαγόνο τύπου IV","Ρυθμός βιοσύνθεσης κολλογονούχων πρωτεϊνών","Angiogenesis","Basement membrane","Collagen type IV","Formation of new vessels","Induction of angiogenesis","Rate of biosynthetic of collagenious proteins","Φυσικές Επιστήμες","Βιολογία","Ιατρική και Επιστήμες Υγείας","Επιστήμες Υγείας","Natural Sciences","Biological Sciences","Medical and Health Sciences","Health Sciences"],"dc:title":["Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση","The correlation of the biosynthesis of basement membrane with angiogenesis"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:05Z"}