Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 60 for “"Angiogenic Factors"”.
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The Unfolded Protein Response Increases Production of Pro-Angiogenic Factors by Tumor Cell Lines
… to the transcriptional induction of several pro-angiogenic factors including vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), interleukin 8 (IL-8) and angiogenin. Using quantitative real-time PCR, we confirmed that a number of UPR inducing conditions (i.e., …
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Silencing Endothelial EphA4 Alters Transcriptional Regulation of Angiogenic Factors to Promote Vessel Recovery Following TBI
… results demonstrate changes in expression of angiogenic factors in the absence of early differences in patterns of vessel formation, which may underlie improved vascular regrowth, as well as outline a potential mechanism wherein the interplay between these factors and EphA4 silencing may lead …
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AMBIENT OXYGEN AVAILABILITY MODULATES EXPRESSION OF VASCULAR ANGIOGENIC FACTORS AND CAPILLARY REMODELING (ANGIOPLASTICITY) IN THE MOUSE BRAIN
… including expression of some of the signaling factors involved in the process during chronic hypoxia and subsequent re-oxygenation. Results indicated that expressions of hypoxia inducible factor-1¿¿ (HIF-1¿¿), vascular endothelial growth factor (VEGF) and erythropoietin (EPO) were increased …
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Characterization of the expression of angiogenic factors in the feline placenta during development and in feline cutaneous squamous cell carcinoma
… We hypothesized that higher expression of pro-angiogenic factors is associated with increased morphological metrics in the LZ, the major vascularized zone. Thus, we aimed to characterize the major changes in morphology and vascular development in the placenta throughout pregnancy in cats, …
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Examining The Role Of Angiogenic Factors And Early Developmental Defects In The Pathogenesis Of Pre-Eclampsia In A Mouse Model, Bph/5
… the pathophysiology of this disorder. Angiogenic factors have been promising biomarkers of PE in women. We found that the angiogenic profile in BPH/5 mice mimics that of women at high risk of developing PE with a decrease in the pro-angiogenic factors vascular endothelial growth factor …
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DIABETES MELLITUS AND THE DYSREGULATION OF ANGIOGENESIS IN TUBERCULOSIS
… DM-associated oxidative stress impairs normal angiogenic processes. I hypothesized that disrupted angiogenic regulation underlies the worsened outcomes observed in DM-TB comorbidity. To investigate this, I profiled angiogenic factors and matrix metalloproteinases in PBMCs and neutrophils …
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Engineering three-dimensional lymphatic vasculature on-chip through biochemical and mechanical stimulus
… this precise control over local extracellular factors, we studied the angiogenic response of lymphatic endothelial cells to different soluble pro-angiogenic factors, which accordingly induced different sprout formation dynamics . We also controlled the vascularization behaviors of lymphatics by …
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The Effects of Angiogenic Growth Factors on Mesenchymal Stem Cell Proliferation and Differentiation to Vascular Cell Fates
… factor (VEGF), two of the best-characterized angiogenic factors, on MSC proliferation and differentiation. We hypothesized that treatment with these two factors could inhibit mural cell character and promote differentiation toward an endothelial cell fate. C3H/10T1/2 cells (a line of MSCs …
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Role of p53 and its isoforms in the expression of FGF-2 and tumoral neovascularization
… gene expression profiles of pro and anti-angiogenic factors regulation following D133p53 and/or p53 knockdown. In particular, D133p53 knockdown resulted in specific down-regulation of Angiogenin and hepatocyte growth factor, whereas the main angiogenic factors FGF-2 and VEGF-A were not …
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Markers and mechanisms of pre-eclampsia in pregnancies complicated by diabetes
… indicates that an increased release of two anti-angiogenic factors, soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin (sEng) from placental trophoblasts into the maternal circulation promotes endothelial dysfunction associated with pre-eclampsia. The aim of this thesis was to …
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Molecular Coordination of Skeletal Muscle Capillary Remodeling in Obesity: Implications for Metabolic Homeostasis and Disease
… network and promoted the expression of pro-angiogenic factors including leptin and vascular endothelial growth factor-A (VEGF-A). To investigate the potential involvement of anti-angiogenic factors in mediating the capillary remodelling response in obesity, I investigated the role of …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Vascular Fetal Programming in a Mouse Model of Preeclampsia
… metabolic needs. The hypoxic placenta releases factors into the maternal circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined to develop preeclampsia have altered cardiovascular adaptations which results in …
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Effects of Recombinant Endothelial Growth Factor 121 Therapy on Maternal Vascular Function and Fetal Vascular Programming in a Mouse Model of Preeclampsia
… metabolic needs. The hypoxic placenta releases factors into the maternal circulation, causing dysfunctional maternal endothelium, and resulting in blood pressure increase and end organ damage. Pregnancies destined to develop preeclampsia have altered cardiovascular adaptations which results in …
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Development of Novel hydrogels for protein drug delivery
… angiogenesis led to the discovery of anti-angiogenic factors, large molecular weight proteins that can block the angiogenic process. The aim of this research is development of poly (vinyl alcohol) (PVA) aqueous solutions that cross-link in situ to form a hydrogel that functions as an …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
… which endothelial cells enhance tumor-expressed angiogenic factors during 2D, static co-culture. The 3D tumor vascular model consists of a central microchannel embedded within a type I collagen hydrogel, through which a range of normal (4 dyn/cm^2), low (1 dyn/cm^2) and high (10 dyn/cm^2) …
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Συσχέτιση της βιοσύνθεσης των βασικών μεμβρανών με την αγγειογένεση
… the therapeutic intervention in the so called "angiogenic diseases" e.g. diabetic retinopathy, chronic inflammation neoplasma. A biochemical method is suggested here for the evaluation of angiogenesis which is based on the fact that during the last stages of angiogenesis there is a need for the …
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Molecular mechanisms of radiation-induced brain injury
… activation of pro-inflammatory transcription factors (e.g., activator protein-1 (AP-1),nuclear factor-κB (NF-κB), and cAMP response element-binding protein (CREB)) and overexpression of pro-inflammatory mediators (e.g., tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte …
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Evaluating the Expression of Angiogenic Mediators in a Mouse Model of Tumor Metastasis
… or a secreted form (sFlt-1) that can inhibit angiogenic signaling. Previous studies have shown that variation in mRNA expression of VEGF and its receptors KDR, sFlt-1 and Flt-1 occurs in pathological angiogenesis, i.e. metastatic tumorigenesis. We hypothesize that the ratio of sFlt-1:Flt-1 …
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
… We measured the expression of a panel of angiogenic factors secreted by GSCs. In comparison with matched non-GSC populations, GSCs consistently secreted markedly elevated levels of vascular endothelial growth factor (VEGF), which were further induced by hypoxia. In an in vitro model of …
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Impacts of Empagliflozin (EMPA) Treatment on Skeletal Muscle Microvasculature in Type 1 Diabetic Rats
… rats served as controls. Capillary content and angiogenic factors were assessed in three separate leg muscles. EMPA+insulin treated rats exhibited better glycemic control, but capillary to fibre ratio and VEGFa mRNA was not impacted by EMPA+insulin treatment in the tibialis anterior. PECAM mRNA …
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