ΜΟΝΟΘΕΡΑΠΕΙΑ ΜΕ ΜΙΑ ΔΟΣΗ ΒΑΛΠΡΟΙΚΟΥ ΝΑΤΡΙΟΥ ΤΗΝ ΗΜΕΡΑ ΣΕ ΠΑΙΔΙΑ. ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗ ΜΕΛΕΤΗ

MONOTHERAPY WITH ONCE DAILY SODIUM VALPROATE WAS GIVEN IN 55 CHILDREN WITH EPILEPSY. FOR 35 PATIENTS (35/55) ALREADY ON SODIUM VALPROATE TWICE DAILY THE SAME DAILY DOSE WAS GIVEN ONCE DAILY. THEY WERE ALREADY FREE OF SEIZURES AND CONTINUED SO AFTER THE CHANGE. 19 OF THEM HAD AN ABNORMAL EEG WHILE ON TWICE DAILY ANDALL ABNORMALITY DISAPPEARED IN 12 AFTER THE CHANGE TO THE ONCE DAILY DOSAGE. IN 20 PATIENTS (20/55) WITH FREQUENT SEIZURES SODIUM VALPROATE WAS GIVEN ONCE DAILY FROM THE START. THEY BECAME FREE OF SEIZURES AND ALL EEG ABNORMALITY DISAPPEARED. TWENTY PATIENTS HAD THEIR SERUM LEVELS ASSESSED EVERY 4 HOURS AND THEIR RESULTS ARE EXPRESSED WITH A SECOND DEGREE CURVE, WHICH SHOWS BETTER THE OPTIMUM RANGE IN RELATION TO THE TIME OF SAMPLING. THE "OPTIMUM" RANGE WHICH WE SUGGEST IS 60-120 MG/L.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1985

Authors dc:creator

• Covanis, Athanasios
• Κοβάνης, Αθανάσιος

• Epilepsies
• Monotherapy
• ONCE DAILY
• Sodium valproate
• Βάλπροϊκό νάτριο
• Επιληψία
• ΜΙΑ ΔΟΣΗ ΤΗΝ ΗΜΕΡΑ
• Μονοθεραπεία
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0381

OAI identifier oai:identifier

oai:10442/0381