Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Epilepsies"”.
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A statistical theory of the epilepsies
A new physical and mathematical model for the epilepsies is proposed, based on the theory of bond percolation on finite lattices. Within this model, the onset of seizures in the brain is identified with the appearance of spanning clusters of neurons engaged in the spurious and uncontrollable …
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Delineation of the genetic causes of complex epilepsies in South African pediatric patients
Background Sub-Saharan Africa bears the highest burden of epilepsy worldwide. A proportion is presumed to be genetic, but this aetiology is buried under the burden of infections and perinatal insults, in a setting of limited awareness and few options for testing. Children with developmental and …
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The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… that therapeutic attempts to reduce ER stress in epilepsies may result in worsening seizure activity and therefore caution against inhibition of ER stress as a neuroprotective strategy for epilepsies.
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Functional consequences of mutations in GRIN2A and GRIN2B associated with mental disorders
… individuals with a range of childhood onset epilepsies, intellectual disability and other neurodevelopmental abnormalities have been found to carry heterozygous gene-disrupting or protein-altering point mutations in GRIN2A and GRIN2B. This thesis addresses the hypothesis that these point …
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Classifying drug-induced epileptic seizures in zebrafish larvae
… for modelling acute seizures and genetic epilepsies. In this project, a mathematical classification model was created with the aim of correctly classifying zebrafish larvae having an (PTZ induced) epileptic seizure. The model also computes biomedical parameters describing behavioural …
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The Role of Inhibitory Interneurons in a Model od Developmental Epilepsy
… We hypothesize that for certain malformation epilepsies, the inhibitory processes that control timing are increased, creating a hyper-synchronous cortex, while the inhibitory processes that control horizontal spread are decreased, allowing the propagation of such activity. Here we have …
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Localization of seizure foci in pediatric populations : development of a predictive pediatric model
… two most common localization-related symptomatic epilepsies: temporal lobe epilepsy (TLE) and frontal lobe epilepsy (FLE). Past findings, primarily with adults, have supported a localizationist model of focal epilepsy. Based on these studies, it was hypothesized that the TLE group would perform …
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Children referred with lennox-gastaut syndrome in the Western Cape of South Africa
… (LGS) is one of the most common refractory epilepsies of childhood with significant morbidity and mortality. However there is paucity of data of this syndrome in resource limited settings (RLS). We sought to delineate the phenomenology, diagnosis, aetiologies, management and outcomes of …
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Investigation of Cell-Type-Specific Effects and Synergistic Interactions Between Genes in Duplication 15q Syndrome
… underlie the treatment resistant nature of some epilepsies including Dup15q syndrome. The results from these studies highlight the role that glial cell dysfunction may play in generating seizures in Dup15q syndrome and could ultimately provide novel avenues for epilepsy treatments.</p>
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Investigation of the GATOR1 complex genes in focal cortical dysplasia and focal epilepsy
… and autophagy. Many diseases, including some epilepsies, arise from mTORC1 dysregulation and are termed ‘mTORopothies’. mTOR dysregulation is therefore hypothesised to be the major factor in the pathology of GATOR1-related epilepsy. To better understand the roles these genes play in causing …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… and how its dysfunction leads to seizures or epilepsies. During my Ph.D. thesis studies, I aimed to characterize the function of Nedd4-2 in regulating neuronal excitability and how epilepsy-associated missense mutations impair such regulation, in order to elucidate the molecular mechanisms …
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Neural Mechanisms and Behaviors in Models of Conditional Nprl2 Loss
The file named "DENTEL-PRIMARY-2022-1.pdf" is the primary dissertation file. Two (2) supplemental video files are also available and may be viewed individually.
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ΜΕΛΕΤΗ ΤΟΥ ΤΟΠΙΚΟΥ ΕΓΚΕΦΑΛΙΚΟΥ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΗΣ ΓΛΥΚΟΖΗΣ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΚΑΙ ΣΥΣΧΕΤΙΣΜΟΣ ΜΕ ΚΛΙΝΙΚΑ ΚΑΙ ΕΡΓΑΣΤΗΡΙΑΚΑ ΔΕΔΟΜΕΝΑ
ΤΡΙΑΝΤΑ ΕΞΗ ΑΣΘΕΝΕΙΣ ΜΕ ΕΣΤΙΑΚΗ ΕΠΙΛΗΨΙΑ ΕΜΕΛΕΤΗΘΗΚΑΝ ΩΣ ΠΡΟΣ ΤΟΝ ΤΟΠΙΚΟ ΕΓΚΕΦΑΛΙΚΟ ΜΕΤΑΒΟΛΙΣΜΟ ΤΗΣ ΓΛΥΚΟΖΗΣ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ΤΗΣ ΤΟΜΟΓΡΑΦΙΑΣ ΕΚΠΟΜΠΗΣ ΠΟΖΙΤΡΟΝΙΩΝ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΙΧΑΝ ΕΠΙΣΗΣ ΠΛΗΡΗ ΕΛΕΓΧΟ ΚΛΙΝΙΚΟ, ΗΛΕΚΤΡΟΕΓΚΕΦΑΛΟΓΡΑΦΙΚΟ ΚΑΙ ΑΚΤΙΝΟΛΟΓΙΚΟ. ΟΙ ΑΣΘΕΝΕΙΣ ΕΠΑΣΧΑΝ ΑΠΟ ΑΝΘΙΣΤΑΜΕΝΗ ΣΤΗΝ …
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ΜΟΝΟΘΕΡΑΠΕΙΑ ΜΕ ΜΙΑ ΔΟΣΗ ΒΑΛΠΡΟΙΚΟΥ ΝΑΤΡΙΟΥ ΤΗΝ ΗΜΕΡΑ ΣΕ ΠΑΙΔΙΑ. ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗ ΜΕΛΕΤΗ
MONOTHERAPY WITH ONCE DAILY SODIUM VALPROATE WAS GIVEN IN 55 CHILDREN WITH EPILEPSY. FOR 35 PATIENTS (35/55) ALREADY ON SODIUM VALPROATE TWICE DAILY THE SAME DAILY DOSE WAS GIVEN ONCE DAILY. THEY WERE ALREADY FREE OF SEIZURES AND CONTINUED SO AFTER THE CHANGE. 19 OF THEM HAD AN ABNORMAL EEG WHILE …