Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 99 for “"Monotherapy"”.
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… to direct tumor cell killing, immunotoxin monotherapy has been shown to induce a secondary anti-tumor immune response through the engagement of T cells. Therefore, the D2C7-IT-induced secondary anti-tumor immune response was investigated using syngeneic mouse glioma models in …
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Influences of first-line oral monotherapy on outcomes in Pulmonary Arterial Hypertension in association with Connective Tissue Disease.
… exist. Aim To measure the impact of first-line monotherapy with bosentan or sildenafil and the introduction of prescribing guidelines on outcomes in PAH-CTD. Methods Following a retrospective analysis of consecutive, incident, treatment-naive PAH-CTD cases identified by the ASPIRE registry, …
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Multidrug-Resistant Hepatitis B Virus Resulting From Sequential Monotherapy With Lamivudine, Adefovir, and Entecavir: Clonal Evolution During Lamivudine Plus Adefovir Therapy
… of MDR HBV strains developed from sequential monotherapy with lamivudine (LAM), adefovir (ADV), and entecavir (ETV) during LAM plus ADV salvage therapy. METHODS: Sera were obtained from 6 patients who had developed sequential resistance to LAM, ADV, and ETV before and during LAM plus ADV …
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Safety and Effectiveness of Antidepressants in Medicaid-Enrolled Pediatric Bipolar Depression
… in terms of- (1) Continuation of antidepressant monotherapy, antipsychotic monotherapy, mood stabilizer monotherapy, antidepressant polytherapy (with antipsychotic or mood stabilizer), antipsychotic-mood stabilizer polytherapy, and 3-class polytherapy regimens during 6 months after initial …
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Effects of combination therapies on age-related macular degeneration
… combined PDT and steroids, and anti-VEGF monotherapy were reviewed, comparing changes in average visual acuity, foveal thickness, and number of injections administered. PDT and anti-VEGF was concluded to be the most efficient of the three, requiring fewer injections while showing an …
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Evaluating the cost-effectiveness of artemisinin-based combination antimalarial drugs and malaria rapid diagnostic tests within the context of effective vector control : case study of Southern Africa
… (i.e. In Kwazulu Natal which switched from SP monotherapy to AL in 2001 and in Mpumalanga which changed from SP monotherapy to AS+SP in 2003) in South Africa. The economic evaluation of use of routine definitive diagnosis as part of malaria case management, using rapid diagnostic tests (ROTs), …
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Emergence of Adefovir-resistant Mutants after Reversion to YMDD Wild-type in Lamivudine-resistant Patients
… lamivudine (LAM)- resistant patients during ADV monotherapy. We determined YMDD mutations and ADV-resistant mutations before and every 3 months during ADV monotherapy in 33 LAM-resistant patients using RFMP method. Reversion to pure YMDD wild-type HBV occurred in 6% (2/33), 9% (3/33), 20% (4/20) …
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The potential immunomodulatory effects of the statins in uveitis
… in the treatment of uveitis as a steroid-sparing monotherapy or as part of combination therapy.
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Developing a co-culture model of ovarian cancer to identify immunotherapies that can overcome TGF-β-induced immunosuppression
… enhanced cancer killing in co-culture. Since LY monotherapy has been clinically ineffective, we aimed to identify effective combination treatments. SHP099, a SHP2 inhibitor that also increased GzmB expression in TGF-β-treated T cells, performed well in co-culture as a monotherapy but did not …
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Causal Inference Methods for Estimation of Survival and General Health Status Measures of Alzheimer’s Disease Patients
… presently treated with no drugs, the Memantine monotherapy, or the Donepezil monotherapy respectively. Switching the patients that are currently on no drug treatment or on Donepezil and Memantine monotherapies to the combined treatment of Donepezil and Memantine will decrease the total number of …
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Συνδυασμός λετροζόλης και κιτρικής κλομιαφαίνης έναντι λετροζόλης στην πρόκληση ωορρηξίας σε γυναίκες με σύνδρομο πολυκυστικών ωοθηκών (PCOS): Συστηματική ανασκόπηση και μετά-ανάλυση / Combination of letrozole and clomiphene citrate versus letrozole monotherapy in inducing ovulation in women with polycystic ovary syndrome (PCOS): A systematic review and meta-analysis
Υπόβαθρο: Το σύνδρομο πολυκυστικών ωοθηκών είναι μια διαταραχή που επηρεάζει το 4-20% των γυναικών αναπαραγωγικής ηλικίας και χαρακτηρίζεται από ανωορρηξία, υπερανδρογονισμό και μεταβολικές διαταραχές. Η πρόκληση ωορρηξίας αποτελεί βασικό στοιχείο της αντιμετώπισης της υπογονιμότητας σε γυναίκες με …
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The change in malaria treatment policy in Uganda : extent of adherence to antimalarial drug policy in Rakai and Kampala Districts
… drug policy in Uganda, from chloroquine monotherapy to combination therapy of CQ+SP for management of uncomplicated malaria. Prescribing practice of health personnel in selected health facilities in Rakai and Kampala Districts is used as a measure of level of adherence to the change in …
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Identification of Markers to Predict Benefit from Trastuzumab Treatment
… associated also with response to trastuzumab monotherapy in clinical samples, suggesting the possibility to treat HER2-addicted tumours with trastuzumab monotherapy. Accordingly TRAR-low, high-NKG2D- and -MHC-II-expressing tumours were associated with response to one cycle of trastuzumab …
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Evaluating Adherence and Health Outcomes among Patients on Concomitant Diabetes, Hypertension, & Hyperlipidemia Treatments Using Marginal Structural Modeling
… therapy and 10.51% of patients were adherent to monotherapy/none. Several socio-demographic and clinical predictors were associated with the different adherence groups. For aim 2, patients who were adherent to triple therapy and double therapy were more likely to have their LDL-C as well as A1C …
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Investigating the potential of enhanced neuroprotection through unfolded protein response inhibition and autophagy induction in neurodegeneration
… in prion-diseased mice beyond the effects of monotherapy alone. These results show that the modulation of autophagy genetically and pharmacologically is neuroprotective in prion-diseased mice to a similar extent to PERK pathway modulation. The combinatorial approach did not increase lifespan …
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Combination Treatment of Angiotensin-II Receptor Blocker and Angiotensin-Converting-Enzyme Inhibitor in Non-Diabetic Renal Disease on Effect of Reducing Proteinuria
… of combined treatment of ACEI and ARB, and monotherapy of each drug in patients with non-diabetic renal disease. METHODS: 266 patients who have non-diabetic renal disease comfirmed by renal biopsy in Ajou university hospital retrospectively reviewed. After reviewing, 83 patients who were …
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Efficacy of sulfadoxine-pyrimethamine with and without artesunate for the treatment of uncomplicated malaria in Mozambique : a randomised controlled trial
… Therefore this RCT was conducted to compare SP monotherapy with AS, plus SP in order to provide further evidence of available treatment options in the region. [Trial design and methods] A prospective multi-centre, open-label, parallel-group randomised clinical trial (RCT) was conducted at 4 …
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ΜΟΝΟΘΕΡΑΠΕΙΑ ΜΕ ΜΙΑ ΔΟΣΗ ΒΑΛΠΡΟΙΚΟΥ ΝΑΤΡΙΟΥ ΤΗΝ ΗΜΕΡΑ ΣΕ ΠΑΙΔΙΑ. ΚΛΙΝΙΚΟΕΡΓΑΣΤΗΡΙΑΚΗ ΜΕΛΕΤΗ
MONOTHERAPY WITH ONCE DAILY SODIUM VALPROATE WAS GIVEN IN 55 CHILDREN WITH EPILEPSY. FOR 35 PATIENTS (35/55) ALREADY ON SODIUM VALPROATE TWICE DAILY THE SAME DAILY DOSE WAS GIVEN ONCE DAILY. THEY WERE ALREADY FREE OF SEIZURES AND CONTINUED SO AFTER THE CHANGE. 19 OF THEM HAD AN ABNORMAL EEG WHILE …
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Identification of new therapeutic targets for undifferentiated pleomorphic sarcoma
… showed high variability, and in vivo, where monotherapy and combination treatment significantly reduced tumour volume. Overall, this work developed novel models of UPS, which were utilised to identify quisinostat as a potential therapeutic option for UPS, demonstrating potent anti-tumour …
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Investigation of potential biomarkers of treatment-resistant schizophrenia
… responders) and those responsive to clozapine monotherapy (clozapine-responsive; TRS) were compared to each other, to those who do not respond to clozapine monotherapy (clozapine resistant; UTRS) and to a healthy control group. Two non-invasive magnetic resonance imaging (MRI) techniques were …
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