ΜΗΧΑΝΙΣΜΟΙ ΠΟΥ ΕΛΕΓΧΟΥΝ ΤΗΝ ΑΡΡΕΝΩΠΟΤΗΤΑ (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΣΕ ΔΥΟ ΣΤΕΛΕΧΗ ΠΟΝΤΙΚΩΝ)

MECHANISMS RESPONSIBLE FOR THE DEFICIENT EXPRESSION OF MALE PHENOTYPE WERE STUDIED. AS EXPERIMENTAL MODEL WE USED THE C57BL/10J MALE MICE WHICH ARE DEFICIENT IN A NUMBER OF MALE CHARACTERISTICS AS COMPARED WITH THE DBA MALE MICE. AS FAR AS TESTOSTERONE IS THE CRUCIAL FACTOR FOR THE DEVELOPMENT OF THE MALE PHENOTYPE, WE STUDIED TESTOSTERONE UPTAKE BY ITS "TARGET-TISSUES", IN THESE TWO STRAINS. IN ADDITION WE STUDIED LOCAL METABOLISM OF TESTOSTERONE IN THE HYPOTHALAMUS PREOPTIC AREA OF THESE TWO STRAINS. TESTOSTERONE IS TAKEN UP BY ALL TISSUES STUDIED IN BOTH STRAINS OF MICE. MOREOVER, IT IS SHOWN THAT TESTOSTERONE IS TAKEN UP BY LIMITED CAPACITY UPTAKE SYSTEMS IN CYTOPLASM AND NUCLEUS, WHICH REPRESENT CYTOPLASMIC AND NUCLEAR RECEPTORS RESPECTIVELY. THE CAPACITY OF UPTAKE SYSTEMS IS THE SAME, WHILE THE EFFICIENCY IS GREATER IN C57 THAN IN DBA. INTHE HYPOTHALAMUS, TESTOSTERONE IS METABOLIZED IN BOTH STRAINS TO 5A REDUCED METABOLITES AND ESTROGENS. THE HYPOTHALAMUS-PREOPTIC AREA OF C57 MALE MICE HASDECREASED AROMATASE ACTIVITY, WHICH IS CONSISTENT WITH THEIR DEFICIENT MASCULINE BEHAVIORAL CHARACTERISTICS.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Authors dc:creator

• Brountzos, Elias
• Μπρουντζος, Ηλίας

• AROMATIZATION
• C57BL/10J DBA/2J MALE MICE
• HYPOTHALAMUS-PREOPTIC AREA
• MALE PHENOTYPE
• TARGET-TISSUES
• Testosterone
• UPTAKE AND METABOLISM
• ΑΡΣΕΝΙΚΟΣ ΦΑΙΝΟΤΥΠΟΣ
• ΑΡΩΜΑΤΟΠΟΙΗΣΗ
• ΙΣΤΟΙ-ΣΤΟΧΟΙ
• ΠΡΟΣΛΗΨΗ ΚΑΙ ΜΕΤΑΒΟΛΙΣΜΟΣ
• Τεστοστερόνη
• ΥΠΟΘΑΛΑΜΟΣ-ΠΡΟΟΠΤΙΚΗ ΠΕΡΙΟΧΗ
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0361

OAI identifier oai:identifier

oai:10442/0361