Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 18 of 18 for “"DBA/2J"”.
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A Behavioral and Anatomical Analysis of Conditioned Taste Aversion in C57BL/6J and DBA/2J Mice
… the common strains C57BL/6J (B6) and DBA/2J (D2), allows for the investigation of phenotypic variation and specific genes underlying the various components of CTA. B6 and D2 mice have previously been characterized in terms of various ingestive behaviors, making these mice ideal for …
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Postnatal Testicular Development in 3 Inbred Strains of Mice.
… of body weight) increased for most strains. The DBA/2J strain increased by 123mg, the C57BL/6J by 84mg and the AKR/J strain by only 45mg. The C57BL/10J strain however was unique in that it showed a decrease of 235mg during this period. The absolute weight of the testes also fell with increasing …
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Functional Analysis of Genomic Variation and Impact on Molecular and Higher Order Phenotypes
… of one of the oldest inbred strains of mice—DBA/2J—the father of the large family of BXD recombinant inbred strains. We analyzed ~100X wholegenome sequence data for the DBA/2J strain, relative to C57BL/6J, the reference strain for all mouse genomics and the mother of the BXD family. We …
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Second Harmonic Generation – A Novel Approach in Retinal Imaging
… loss of axons in a mouse model of glaucoma (DBA/2J); and 3) if elevated levels of intraocular pressure affect MT integrity. Our results validate SHG imaging as a promising tool to research the biophysics of MTs and its possible role in neurodegenerative disorders</p>
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Characterization of a novel recombinant inbred mouse model of high fear
… mapping approaches to generate a novel fearful DBA/2JHd x C3H/HeJHd recombinant inbred mouse strain that was selectively bred for a high fear-sensitized acoustic startle response. The C3H-like recombinant inbred (C3HLRI) mouse strain, compared to its background strain DBA/2J mice, exhibit an …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… investigation as a treatment for glaucoma. The DBA/2J mouse strain develops a naturally occurring pigmentary glaucoma as a result of increased intraocular pressure (IOP). At 1 month of age DBA/2J mice received a single intramuscular injection of rAAV carrying either Epo or EpoR76E. The mice were …
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ETHANOL REGULATION OF GLUCOCORTICOID RESPONSIVE GENES
… (2 g/kg) in the prefrontal cortex (PFC) of DBA/2J mice. Functionally, Sgk1 is an important focal point of intracellular signaling cross-talk through which the cell surface receptors, nuclear receptors, and cellular stress pathways converge to control many cellular processes including …
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Genetic Diversity And Sexual-Dimorphisms Are Important Contributors To The Inflammatory Response Induced By Endotoxin
… verschieden Mausstämmen (A/J, C57BL6/J, DBA/2J, BALB/cJ und AKR/J) bakterielles Endotoxin (Lipopolysaccharid, LPS) intraperitoneal injiziert. Als Ausdruck der entzündlichen Antwort wurden Plasmaspiegel der Zytokine Tumor Nekrose Faktor alpha (TNF-a) und Interleukin 10 (IL-10) mittels …
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Bone Properties of Recombinant Inbred Line - BXD Mouse
… including progenitor C57BL/6J (n=16) and DBA/2J (n=15), and two first filial generations (D2B6F1 and B6D2F1). Bones were collected from 10 to 14-week old females and males (N≥3 each group) and bone parameters were measured at three different sites by high resolution 3D micro-computed …
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USING SHORT-TERM BEHAVIORAL SELECTION TO EVALUATE THE HERITABILITY OF ETHANOL-INDUCED LOCOMOTOR SENSITIZATION AND ITS RELATIONSHIP TO ETHANOL’S POSITIVE MOTIVATIONAL EFFECTS IN MICE
… Genetically heterogeneous C57BL/6J (B6) x DBA/2J (D2) F2 mice were generated from B6D2F1 progenitors, phenotyped for the expression of locomotor sensitization, and bred for high (HLS) and low (LLS) expression of this behavior. A secondary goal was to characterize possible line differences …
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Characterization of SERCA function in the hippocampal and prefrontal cortex regions of the brain from C57 and D2 mx mice
… Moreover, recent evidence has shown that the DBA/2J (D2) mdx mouse model of DMD presents with cognitive dysfunction and a shift towards amyloid beta (Ab) production in the hippocampus and prefrontal cortex (PFC). However, this was not observed in the traditional, yet less severe model of DMD, …
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Insights into the piRNA pathway through 16 strains of mice
… specific mouse strains (C57BL/6NJ, BALB/cJ, A/J, DBA/2J, AKR/J, NZO/HlLtJ, NOD/ShiLtJ) where these transposable elements (TE) are found. Conversely, strains lacking this TE insertion do not show similar expression patterns. In sum, this work offers new perspectives on piRNA dynamics and their …
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Myelin Gene Expression: Implications for Alcohol Abuse and Dependence
… ethanol behaviors between C57BL/6J (B6) and DBA/2J (D2) mice. Our laboratory and others have also shown MAGE is reduced in PFC of alcoholics. Herein, I have extended these findings through expression profiling of PFC into chronic models of ethanol self-administration from non-human primates …
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Molecular Approaches to the Genetics of Obesity: Mapping and Characterization of the Murine Diabetes (db) Gene
… between the progenitor strains (C57BL/6J and DBA/2J) in the development of overt diabetes. In order to increase the density of probes in the region of db, flowsorting of a 4:6 Robertsonian chromosome was accomplished, establishing a library ~72% pure for chromosomes 4 and 6. In addition, …
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Evaluation of age differences in locomotor activity following psychostimulant administration in adolescent versus adult mice
… different inbred strains (C57BL/6J, BALB/cByJ, DBA/2J, FVB/NJ) were screened for differences in locomotor stimulation following cocaine. The greatest difference in stimulation between age groups was observed in C57BL/6J, but BALB/cByJ and female FVB/NJ mice also showed attenuated stimulation in …
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Genetic Variation and Sex Mediate Differential Responses to ∆-9-tetrahydrocannabinol among Inbred Mice
… divergent inbred mouse strains—C57BL/6J (B6) and DBA/2J (D2). To identify variation in THC response we use the cannabinoid-induced tetrad test which quantifies the strength of agonist mediated cannabinoid receptor signaling by measuring the level of motor activity, nociception, and hypothermia …
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Development and application of OmpT-based middle down proteomics
… in the same high-mass region from strain DBA/2J. Through the comparison of identified OmpT peptides, some interesting single nucleotide polymorphism (SNP) examples are found between the two strains. These findings verify the robustness and efficacy of the middle-down performance in …
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ΜΗΧΑΝΙΣΜΟΙ ΠΟΥ ΕΛΕΓΧΟΥΝ ΤΗΝ ΑΡΡΕΝΩΠΟΤΗΤΑ (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΣΕ ΔΥΟ ΣΤΕΛΕΧΗ ΠΟΝΤΙΚΩΝ)
… OF MALE CHARACTERISTICS AS COMPARED WITH THE DBA MALE MICE. AS FAR AS TESTOSTERONE IS THE CRUCIAL FACTOR FOR THE DEVELOPMENT OF THE MALE PHENOTYPE, WE STUDIED TESTOSTERONE UPTAKE BY ITS "TARGET-TISSUES", IN THESE TWO STRAINS. IN ADDITION WE STUDIED LOCAL METABOLISM OF TESTOSTERONE IN THE …