Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"TARGET-TISSUES"”.
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Identification of Relaxin-Target Tissues and Target Cells in the Pig
… may therefore mediate relaxin's effects in its target tissues of pigs.
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The mammary nipples are vital endocrine target tissues for relaxin in the rat
Restriction data tranferred 2014-07-01T11:31:36-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Relaxin: Target Tissues and Effects on Uterine Contraction in Vivo and in Vitro in the Rat
Possible target tissues for relaxin in estrogen-primed ovariectomized rats were identified by determing (1) the tissue distribution of injected ('125)I-labeled relaxin (('125)I-relaxin) in vivo and (2) the changes in cyclic AMP (cAMP) levels in several tissues following incubation with relaxin in …
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The VH repertoire and clonal diversification of B cells in myositis and vasculitis
… antigen-driven adaptive immune responses in the target tissues of the autoimmune disorders myositis and vasculitis, two autoimmune disorders characterised by a wide range of autoantibodies which have been implicated in the pathological mechanisms of these diseases. This study aimed to test the …
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I.~fluorine-18 Labeled Corticosteroids and Progestins for Receptor-Based Imaging of the Brain and of Breast Tumors. II.~Synthesis and NMR Spectrum of (carbon-13(18))-Meso-Hexestrol
The presence of steroid receptors in certain target tissues and tumors provides an avenue for monitoring pathological changes through the use of positron emission tomography and an appropriate fluorine-18 labeled ligand. We have prepared fluorinated analogs of six natural and synthetic …
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Analysis of Estrogen and Antiestrogen Receptor Complexes
… the structure and relatedness of ER in different target tissues and species. In addition, I have characterized the first efficient and selective affinity labeling estrogen, ketononestrol aziridine (KNA).
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Estrogen Receptor and Progesterone Receptor Synthesis and Degradation in Target Cells
… factors in maintaining hormone responsiveness in target tissues. It was the intent of this study to determine the turnover of the estrogen receptor (ER) and progesterone receptors (PR) in rat uterine and human breast cancer cells, respectively, and to examine the effect of estrogen and progestin …
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Exposures and the Impacts on the Epigenome that Persist from Youth to Adulthood and Intergenerationally
… changes of the epigenome in healthy non-target tissues. My findings promote the cautionary application of decitabine as a hypomethylating agent, as it paradoxically alters DNA methylation where the long-term effects on non-target tissues remain unknown. Together my research contributes to …
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Design, Synthesis and Biological Properties of Estrogen Receptor Binding Breast Tumor Localizing Agents
… they were concentrated selectively in estrogen target tissues of the immature female rat and estrogen receptor containing DMBA induced mammary tumors in mature female rats by a mechanism presumably involving the estrogen receptor. The radiobrominated 11(beta)-methoxy estradiol was more effective …
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Regulation of Metabolic Processes by Micrornas and Class I Histone Deacetylases
… and elevated oxidative capacity of insulin-target tissues. Taken together, our findings reveal that miR-378 and miR-378* function as integral components of the regulatory circuit formed by PGC-1beta and nuclear hormone receptors to control the overall oxidative capacity and energy …
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The Use of Ultrasound-Targeted Microbubble Destruction in Mediated Delivery of a Gadolinium Magnetic Resonance Imaging Contrast Agent Into Fibroblast Cells In Vitro
… Gd-based MRI contrast agents by ultrasound-targeted microbubble destruction into fibroblast cells in vitro is presented. First, MRI contrast agents Gd-F-DOTP-ME and Gd-DOTA-4iBA are shown to associate with liposome microbubbles used as ultrasound contrast agents. Repeated washings with …
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Design, synthesis, and biochemical evaluation of three types of hexestrol-based probes for estrogen receptor: Fluorine-18 radiopharmaceuticals, bivalent ligands and diazirine photoaffinity reagents
… compounds with moderate selective uptake in target tissues (uterus, ovaries) and substantial receptor-mediated uptake in secondary tissues (thymus, muscle, kidney, fat).
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Biochemical studies on Oestradiol 17β in human mammary tumours and chemically induced rat mammary tumours
… similar to those occurring in normal oestrogen target tissues such as uterus. The possession of such components may be related to the hormone responsiveness of the tumour. An established method for measuring binding of tritium labelled oestradiol to human mammary tumours by in vivo infusion …
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ΜΗΧΑΝΙΣΜΟΙ ΠΟΥ ΕΛΕΓΧΟΥΝ ΤΗΝ ΑΡΡΕΝΩΠΟΤΗΤΑ (ΠΕΙΡΑΜΑΤΙΚΗ ΜΕΛΕΤΗ ΣΕ ΔΥΟ ΣΤΕΛΕΧΗ ΠΟΝΤΙΚΩΝ)
… WE STUDIED TESTOSTERONE UPTAKE BY ITS "TARGET-TISSUES", IN THESE TWO STRAINS. IN ADDITION WE STUDIED LOCAL METABOLISM OF TESTOSTERONE IN THE HYPOTHALAMUS PREOPTIC AREA OF THESE TWO STRAINS. TESTOSTERONE IS TAKEN UP BY ALL TISSUES STUDIED IN BOTH STRAINS OF MICE. MOREOVER, IT IS SHOWN …
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Estrogen Regulation of Gene Expression and Analysis of the Role of the Coregulator, Repressor of Estrogen Receptor Activity (Rea)
… functional activities of REA in diverse estrogen target tissues in vivo, I have used targeted disruption to ablate the REA gene in mice. Genotyping revealed that homozygous animals are not viable, suggesting a crucial role for REA in early development. The viability of heterozygous animals is …
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Sphingosine-1-phosphate in mast cell-mediated allergic responses
… chronic inflammation and mature in peripheral tissues from bone marrow-derived progenitors that circulate in the blood as immature precursors. Mast cell progenitors are likely to encounter the serum-borne bioactive sphingolipid metabolite, sphingosine-1-phosphate (S1P), during migration to …
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Obesity, 11β-hydroxysteroid dehydrogenase and metabolic changes in the pathogenesis of idiopathic intracranial hypertension
… tissue), are potential glucocorticoid target tissues expressing 11β-HSD1. Metabolomic analysis identified a unique biofluid metabolite biomarker profile, with potential implications for IIH pathogenesis. We established the therapeutic efficacy of weight loss in IIH (improving headaches, …
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Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease
… conversion to active sex steroids in peripheral target tissues. In contrast the conversion of DHEAS to androgens first requires cleavage of the sulfate group, catalysed by the microsomal enzyme steroid sulfatase (STS). Conversely, DHEA is converted to inactive DHEAS by the activity of the …
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Pharmacokinetic Evaluation of the Blood: Tissue Relationship in Poultry: Screening for Antibiotic Residues in Chicken Muscle
… determined in samples collected from edible tissues (e.g. muscle, liver, skin, fat) which can lead to a loss of valuable product. Additionally, variations between different edible tissues and products require the development and use of specific analytical procedures. This dissertation …
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A Novel Link Between Oxidative Stress Proteins and Estrogen Receptor Alpha-Mediated Gene Expression
… binding to estrogen receptor alpha (ERalpha) in target cells, interaction with estrogen response element (ERE)-containing DNA, recruitment of coregulatory proteins, and modification of estrogen responsive genes. Because DNA-induced conformational changes in ERalpha structure alter complex …
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