Development of a multi-particulate formulation of viable bacteria for oral and vaginal delivery

The aim of this research project was to develop multi-particulate dosage forms for delivery of lactic acid bacteria: (a) the development of an oral dosage form containing a high concentration of viable, genetically modified, IL-10 producing Lactococcus lactis (b) the development of a formulation for delivery of health-promoting strains of lactic acid bacteria (referred to as probiotics) to the vagina. In addition to the viability of the lactobacilli strains incorporated in the formulation the vaginal retention time and spreading of the formulation in the vaginal cavity are essential quality parameters of this vaginal formulation. Chapter 1 reviews the use of genetically modified Lactococcus lactis and probiotic Lactobacillus strains as therapeutics in the treatment of Crohn’s disease and bacterial vaginosis, respectively. The strategies used to stabilise lactic acid bacteria in solid dosage forms and the processing techniques used to manufacture the oral and vaginal dosage forms are also discussed in this introductory chapter.

Author dc:creator

• Poelvoorde, Nele

Contributors dc:contributor

• Remon, Jean Paul
• Vervaet, Chris

• Medicine and Health Sciences
• skim milk: COATING POLYMERS
• CROHNS-DISEASE
• lactose
• Eudragit
• pellets
• ileum targeting
• recombinant Lactococcus lactis
• layering
• viability
• BACTERIA
• SURVIVAL
• INTERLEUKIN-10

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://biblio.ugent.be/publication/610271
https://biblio.ugent.be/publication/610271/file/4334952

OAI identifier oai:identifier

oai:archive.ugent.be:610271