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Showing 1 to 20 of 41 for “"Eudragit"”.
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The effect of nanoclays on the properties of aspirin modified enteric polymer prepared by hot-melt mixing
… 10 -- 30% w/w are melt-mixed with a plasticized Eudragit L100-55 in a batch mixer for 5 minutes at 100 C which is above the plasticized polymer's glass transition temperature (Tg) and below the ASP's melting point. Processing ASP with Eudragit L100-55 under these conditions does not promote …
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DEVELOPMENT OF A NEW CONTROLLED RELEASE DOSAGE FORM OF ACETYLSALICYLIC ACID
… were microencapsulated in the laboratory, using Eudragit L30D (an aqueous based enteric coating resin) and a fluidized bed coating apparatus. Portions of the microencapsulated granules were compressed into tablets. Both the ASA tablets and granules were compared with commercially available ASA …
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Physicochemical characterization of solid dispersions prepared using hot-melt extrusion technology
… (PVP) as hydrophilic carriers, whereas PVP or Eudragit 4155F was used to prepare the hot- melt extruded solid dispersions of CX. The solid state properties of the prepared solid dispersions were characterized using differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) …
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Entwicklung eines lösungsmittelfreien Befilmungsverfahren für feste Arzneiformen
… auf Polyacrylatbasis zwei Retard- (Eudragit RS PO, RL PO) und ein magensaftresistenter Filmbildner (Eudragit L100-55) ausgewählt. Als Weichmacher dienten Triethylcitrat (TEC), Diethylphathalat (DEP) und Dibutylsebacat (DBS). <br> <br>Für diese Kombinationen wurde ein Verfahren zur …
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Design and evaluation of hot melt extruded transdermal patches.
… The feasibility of delivering ibuprofen from Eudragit RS PO-based extruded patches was investigated. The formation of solid solutions with high drug loading (35% w/w) was achieved in relatively stable extruded Eudragit RS PO matrices under dry conditions. However, these systems were associated …
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Characterisation of drug loaded insoluble polymeric matrices prepared by hot melt extrusion technology for drug delivery applications.
… profiles for targetted drug delivery. Eudragit RL PO and RS PO are insoluble polymers which remain intact across the physiological pH range and represent a largely understudied category of materials as polymeric matrices for drug delivery.<br/>The physical and chemical characteristics …
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Natrium-Carboxymethylstärke und Konjac-Glucomannan als abbaubare Hilfsstoffe für das Colon-Targeting
… weitere Filmbildner wurden Ethylcellulose (EC), Eudragit® RS und Eudragit® NE verwendet, wobei für Na-CMS nur EC als zweiter Filmbildner verwendet werden konnte. In einer statischen Permeationszelle konnten isolierte Filme auf ihre Stabilität und enzymatische Abbaubarkeit untersucht werden. Bei …
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Development of hot-melt extrusion as a novel technique for the formulation of oral solid dosage forms
… was also embedded in a methacrylate copolymer (Eudragit® EPO) matrix to produce solid dispersions by hot-melt extrusion processing. The obtained granules were incorporated into orally disintegrating tablets (ODTs). The tablets were developed by varying the ratio of superdisintegrants such as …
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Development and evaluation of oral solid dosage forms for colonic delivery of drugs for the treatment of cystinosis.
… profile of the drug by coating pellets with Eudragit FS30D - a pH-sensitive polymer. The described dosage forms should selectively deliver the drug to the colon through pH-dependent dissolution of the polymer coating at colonic pH conditions (pH 7.4), thereby minimising the incidence of any …
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Solubility Enhancement via Melt Extrusion: Drug-polymer Solubility, Physicochemical Characterization and Quality by Design
… chemical characterization of the ibuprofen and Eudragit<super>®</super> E PO system. A phase diagram is predicted based on the understanding of the relationship between temperature, ratio of ibuprofen and the Gibbs free energy. Room temperature miscibility of the two components is demonstrated …
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Tailoring electrospun nanofibers and electrosprayed nanoparticles to enhance cellular uptake of low bioavailability drugs
… MeOH was used to make hemin soluble. PVP-360 and eudragit L 100 were initially selected to make hemin formulations by electrospinning. A variety of electrospinning conditions were attempted and optimal conditions for producing high quality fibers were found to be 0.5 mL/hr, 14 cm (distance) and …
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Development and Characterization of Sustained-Release Formulations via Novel Hot Melt Extrusion Techniques
… (APAP) with the hydrophobic carriers Eudragit® RL PO and Eudragit® RS PO by HME/P-CO2 and to evaluate the buoyancy efficiency through <em>in-vitro</em> methods. Moreover, scanning electron microscopy (SEM) was utilized to visually investigate the morphological change of the matrix; (3) …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
… of Keltone by extrusion using water and Eudragit EPO as plasticizers, and Diphenhydramine Hydrochloride and Clotrimazoleas as active pharmaceutical ingredients is assessed. The amount of residual water in the extrudates is determined by thermogravimetric analysis. The thermal transitions …
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Development of processes using modified proteases for the reduction of felting and shrinkage of wool textiles
… coupled to reversibly soluble-insoluble polymer Eudragit SI00 and LI00. Different coupling reactions in terms of polymer concentration, different washing methods to remove unmodified protease, presence or absence of l-Ethyl-3-(dimethylaminopropyl)carbodiimide hydrochloride (EDC) crosslinking …
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Study of controlled release of active pharmaceutical ingredients from functionalized nanoclays and polymer matrices
… parameters by comparison with the polymer. The Eudragit E100/ DIK-Na+ mixture produced by batch melt mixing showed an API solid dispersion whereas the Eudragit E100/ IND system produced an API solid solution. These different morphologies were anticipated by calculating API and polymer solubility …
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Vergleichende Untersuchungen von Delayed Release-Systemen in Abhängigkeit von Wirkstoffeigenschaften
… von überzogenen Tabletten festgestellt. 2. Eudragit S100, ein Filmbildner, der sich bei einem Schwellen-pH-Wert von etwa 7,5 löst, ergab für Hydrocortisontabletten Überzüge, die nach Herstellung bei sauren pH-Werten bis einschließlich pH 7,0 stabil waren, jedoch nach einer Lagerung von 12 …
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Development of nanoparticles for oral delivery of insulin
… Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic …
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Study of controlled release of dapsone from modified montmorillonite and polymer matrices
… and their combination with an anionic copolymer (Eudragit S100). The effects of the excipients on the API dissolution rate were studied from their release profile in simulated intestinal fluid (pH=7.4) at 37+/-0.5 C. In the first part of the research, ionizable Dapsone was intercalated in the …
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Characterization of Drug-Loaded Milled Extrudate Particles Produced by Hot Melt Extrusion Technology for Dry Powder Inhalers
… (SB) and Mannitol (MAN) on the hydrophobic Eudragit RL PO (ERLPO) polymer. Ball milling and air-jet milling were utilized to have powder with a particle size range that is required for inhalation. Air-jet milled formulations shopromising particle size results compared to ball milled …
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Fused deposition modelling three-dimensional printing of solid dosage forms
… Formulations containing Soluplus® or HPC with Eudragit RLPO provided zero-order sustained release of theophylline (THP). Fixed-dose bilayer floating tablets were also manufactured. This thesis displayed the ability of FDM-3DP to manufacture bespoke floating tablets using pharmaceutical …
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