Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers

The objective of this doctoral thesis was to develop by means of a simple, flexible and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide).

Grantor dc:publisher

Ghent University. Faculty of Pharmaceutical Sciences

Year dc:date

2008

Author dc:creator

• Verhoeven, Ellen

Contributors dc:contributor

• Remon, Jean Paul
• Vervaet, Chris

• Medicine and Health Sciences

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://biblio.ugent.be/publication/470393
https://biblio.ugent.be/publication/470393/file/4334888

OAI record oai:identifier

https://biblio.ugent.be/oai?verb=GetRecord&metadataPrefix=oai_dc&identifier=oai%3Aarchive.ugent.be%3A470393