{"id":{"repo_id":"ghent","oai_identifier":"oai:archive.ugent.be:470393"},"canonical_url":"https://search.dev.ndltd.org/etd/ghent/oai:archive.ugent.be:470393","repository":{"repo_id":"ghent","name":"Ghent University","base_url":"https://biblio.ugent.be/oai"},"display":{"title":"Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers","abstract":"The objective of this doctoral thesis was to develop by means of a simple, flexible and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide).","abstract_html":"The objective of this doctoral thesis was to develop by means of a simple, flexible and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide).","abstract_has_math":false,"creators":["Verhoeven, Ellen"],"institution":"Ghent University. Faculty of Pharmaceutical Sciences","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Remon, Jean Paul","Vervaet, Chris"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2008,"date_issued":"2008","date_published":"2008","updated_at":"2026-07-24T02:23:05Z","subjects":["Medicine and Health Sciences"],"languages":["eng"],"rights":["info:eu-repo/semantics/openAccess"],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://biblio.ugent.be/publication/470393","https://biblio.ugent.be/publication/470393/file/4334888"],"render_values":[{"text":"https://biblio.ugent.be/publication/470393","href":"https://biblio.ugent.be/publication/470393","code":true},{"text":"https://biblio.ugent.be/publication/470393/file/4334888","href":"https://biblio.ugent.be/publication/470393/file/4334888","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/1854/LU-470393","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Remon, Jean Paul","Vervaet, Chris"]},{"key":"dc:creator","label":"Author","values":["Verhoeven, Ellen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2008"]},{"key":"dc:publisher","label":"Institution","values":["Ghent University. Faculty of Pharmaceutical Sciences"]},{"key":"dc:type","label":"Dc Type","values":["dissertation","info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Medicine and Health Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://biblio.ugent.be/publication/470393","http://hdl.handle.net/1854/LU-470393","https://biblio.ugent.be/publication/470393/file/4334888"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["The objective of this doctoral thesis was to develop by means of a simple, flexible and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide)."]},{"key":"dc:format","label":"Dc Format","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers"]}]}],"canonical_facts":{"dc:contributor":["Remon, Jean Paul","Vervaet, Chris"],"dc:creator":["Verhoeven, Ellen"],"dc:date":["2008"],"dc:description":["The objective of this doctoral thesis was to develop by means of a simple, flexible and continuous procesesing technique (i.e. hot-melt extrusion) a multiparticulate dosage form with zero-order sustained-release properties. This study demonstrated that the in vitro and in vivo drug release kinetics could be varied by selecting a formulation with an appropriate ratio of lipophilic and hydrophilic polymers, and by changing the particle size and/or molecular weight of the hydrophilic polymer (i.e. xanthan gum and polyethylene oxide)."],"dc:format":["application/pdf"],"dc:identifier":["https://biblio.ugent.be/publication/470393","http://hdl.handle.net/1854/LU-470393","https://biblio.ugent.be/publication/470393/file/4334888"],"dc:language":["eng"],"dc:publisher":["Ghent University. Faculty of Pharmaceutical Sciences"],"dc:rights":["info:eu-repo/semantics/openAccess"],"dc:subject":["Medicine and Health Sciences"],"dc:title":["Hot-melt extrusion as processing technique for multiparticulate dosage forms containing lipophilic and hydrophilic polymers"],"dc:type":["dissertation","info:eu-repo/semantics/doctoralThesis","info:eu-repo/semantics/publishedVersion"]},"updated_at":"2026-07-24T02:23:05Z"}