Trans-skull Ultrasound for Imaging and Therapy

Ultrasound has emerged as a novel modality for the treatment and imaging of brain diseases. When enhanced by circulating microbubble agents, which scatter sound and vibrate in response to the incident ultrasound, it can enable a range of new therapeutic interventions and open new possibilities for imaging. Despite these advancements, the skull remains a major challenge both for therapy and imaging. This work proposes methods for fast, frequency-selective passive reconstruction of the acoustic field through human skull with applications including improved targeting for exploitation of nonlinear acoustic effects in the brain, controlling the microbubble dynamics, and super-resolution imaging.

Level thesis:degree_level

Doctoral

Department dc:contributor.department

Mechanical Engineering

Grantor dc:publisher

Georgia Institute of Technology

Year dc:date.issued

2020

Author dc:creator

• Schoen, Scott J.

Advisor dc:contributor.advisor

• Arvanitis, Costas

Committee members dc:contributor.committeemember

• Cunefare, Kenneth
• Degertekin, F. Levent
• Emelianov, Stanislav
• Sabra, Karim
• Schoen Jr, Scott J.

• Ultrasound
• Focused Ultrasound
• Angular Spectrum
• Brain
• Skull
• Microbubbles
• Imaging
• Super-resolution
• Nonlinear Acoustics

Language dc:language.iso

en_US

Handle dc:identifier.uri

http://hdl.handle.net/1853/64174

OAI identifier oai:identifier

oai:repository.gatech.edu:1853/64174