Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 8518 for “"Brain"”.
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Monitoring brain neurochemistry after brain trauma
… monitoring of cerebral metabolites in traumatic brain injury (TBI) patients. Through a series of in-vitro and in-vivo studies, this research addresses the critical need for enhanced sensitivity and specificity in brain metabolite monitoring. The integration of these sensors with existing clinical …
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Recognizing Brain Regions in 2D Images from Brain Tissue
… visualization of the anatomy of the brain, capturing physical characteristics like the size and shape of different regions of the brain or the presence of abnormalities such as tumors. Whereas sMRI are more commonly taken in vivo, the neuropathology of many neurodegenerative …
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A Brain for Language and the Language of the Brain
… the problem of coding of complex spaces by the brain. We investigate a case of animal communication, that of songbirds. We show that there exists in the auditory brain of canaries a topographic representation of song, whereby song components are mapped into unique patterns of activity, …
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Characterising In Vivo Brain Function Following Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is the most complex disease in the most complex organ and a public health emergency. Sometimes called a silent epidemic, there are at least 50 million TBIs each year globally. This incidence translates to half the world’s population having at least one TBI in their …
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On Brain Oedema
Traumatic brain injury and bacterial meningitis may at a glance appear as two different disease entities. The host reaction, however, to both trauma and infection involves a strong inflammatory response, with the classical symptomology of rubor, tumor, calor, dolor et functio laesa. Tumor, …
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Spatiotemporal brain imaging
Understanding how the human brain works, in both health and disease, requires data with both high spatial and temporal resolution. This thesis develops and applies a spatiotemporal neuroimaging method. I describe a linear estimation inverse approach, which is a method for the combination of …
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Regulation of Brain-Derived Neurotrophic Factor in the Adult Mouse Brain
In the adult central nervous system (CNS) brain-derived neurotrophic factor (BDNF) has been implicated in neuroprotection and synaptic plasticity among other functions. However, relatively little is known of its regulation. In this thesis, we attempted to learn more about BDNF regulation by means …
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Brain Bioavailability Of Polyphenols: Implications For Delivery Of Brain Health Benefits
… active agents with potential for targeting brain benefits. However, little is known regarding the ability of the polyphenols or their metabolites from polyphenol-rich products to cross the blood-brain-barrier, and be available for biological action. Furthermore, additional insight is needed …
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Mechanics of blast-induced traumatic brain injury in porcine brain tissue
<p>Blast-induced traumatic brain injury (bTBI) often results from the detonation of improvised explosive devices (IEDs) in war settings. However, the material properties of the brain and their changes during and after bTBI are currently not well understood. Characterizing brain tissue is …
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
… is the principal determinant of the final brain cytoarchitecture. However, we have only limited knowledge about the migratory pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing forebrain. I …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
<p>Traumatic brain injuries (TBIs) are a common form of head injury, with mild TBIs (mTBIs) making up 75-90% of the TBI severity scale. It’s been suggested that repetitive mild TBIs (rmTBIs) may enhance effects of Alzheimer’s Disease (AD). With dementia linking TBI and AD together, we investigated …
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Morphology of Brain Sulci Trabeculae and its effect on Brain during Impacts
<p>Traumatic brain injury (TBI) is an intracranial injury caused by direct contact or non-contact head impacts to the brain. TBI is a major problem that accounts for high incidents of hospitalizations each year. Thus, it is important to understand and predict the occurrence of TBI in an impact. It …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
… of humans is marked by a rapid expansion in brain size. Efforts to study human brain evolution have characteristically relied on anatomical and genomic comparisons between adult ape brains, meaning that the molecular mechanisms underlying human-specific brain expansion remain largely unknown. …
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Paediatric traumatic Brain Injury: The relationship between Intracranial Pressure and Brain Oxygenation
… of care for patients with severe traumatic brain injury (TBI). The primary goal of ICP treatment is to preserve brain oxygenation, and since brain oxygenation is usually not measured, the control of ICP is used as a surrogate marker. However studies indicating that cerebral hypoxia/ischemia …
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Brain drain to brain gain? : return migration of Indian information technology professionals
Thesis (M.C.P.)--Massachusetts Institute of Technology, Dept. of Urban Studies and Planning, 2003.
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The regulation of brain serotonin concentrations by dietary factors affecting brain tryptophan
… concentrations of tryptophan in rat plasma and brain and of serotonin in rat brain. To determine whether these normally-occurring changes in plasma and brain tryptophan could account for the variation in brain serotonin, we injected rats with different doses of L-tryptophan and measured the …
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The Preterm Social Brain
Nearly 15 million babies are born prematurely (
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MICROGLIA-SUFFICIENT BRAIN ORGANOID
Embryonic primitive macrophages colonize the brain where they differentiate into microglia. Microglia were shown to contribute to brain development in animal models but their roles in human brain development remain poorly understood due to the lack of tissue access. The generation of brain …
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