The <em>In Vitro</em> Cellular Uptake and Physiochemical Properties of Tocotrienols.

<p>This research, focusing mainly on tocotrienols, includes two parts. The first part concerns the uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E.</p><p>In the cellular study our results suggested that position 5 of chroman head and side-chain are very important in determining the uptake of tocotrienols and growth inhibition of PC-3 cells. The uptake and growth inhibition are not necessarily related to the antioxidant properties of tocotrienols.</p><p>Of the physiochemical studies, the results suggested that the antioxidant properties of vitamin E are due to the phenolic O-H group. In ethanol solution, each tocotrienol has a higher oxidation potential than its corresponding tocopherol. The oxidation potentials of vitamin E are in the order of&#945;-form < &#947;form < &#948;-form. The theoretical calculations show that the side chains of tocotrienols are less ordered than those of tocopherols.</p>

Name thesis:degree_name

MS (Master of Science)

Level thesis:degree_level

Thesis - restricted

Discipline thesis:degree_discipline

Chemistry

Year dc:date.issued

2003

Author dc:creator

• Zuo, Tianming

• PC-3
• Tocopherols
• Tocotrienols
• HPLC
• DFT
• Ab Initio
• IR
• Cyclic Voltammetry
• Chemistry
• Physical Sciences and Mathematics

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/780

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-1937