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Showing 1 to 20 of 94 for “"PC-3"”.

  1. Evaluation of therapy for canine intracranial neoplasia using PAC-1, a novel and potent procaspase-3 activator

    Schlein, Lisa JanelleUniversity of Illinois at Urbana-Champaign2018

    … small molecule activator of procaspase-3 (PC-3), with orphan drug status for the treatment of human glioblastoma multiforme. PC-3 is frequently overexpressed in malignantly transformed tissues, providing an opportunity to selectively induce apoptosis in cancer cells with dysregulated …

    uiuc Repository record

  2. Impact of human blood plasma-derived protein corona on extracellular vesicle uptake

    Somersalo, PetterHelsingfors universitet2017

    … In the current study, the uptake of PC-3-derived EVs into PC-3 cells was investigated. Moreover, the impact of a human blood plasma-derived protein corona on said uptake was assessed. EVs were isolated from collected PC-3 cell culture medium using differential centrifugation. …

    helsinki Repository record

  3. Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen

    Hardenberg, Sandra Gräfin von2012

    … von LPXN in Prostatakarzinomzellen (PCa) ist sowohl die Migrations- als auch die Invasionsfähigkeit der Zellen erhöht. Untersuchungen des Zelladhäsionsmoleküls p120CTN in den PCa-Zelllinien PC-3 und DU 145 zeigen, dass die Überexpression von LPXN in einer reduzierten Expression von …

    goettingen Repository record

  4. Regulation Of Membrane-Type 1 Matrix Metalloproteinase In Prostate Cancer

    Sroka, Isis CalsoyasThe University of Arizona.2007

    … DU-145 cells, and highly expressed in invasive PC-3 and PC-3N cells. Using MT1-MMP promoter reporters and mobility shift assays, we show that Sp1 regulates MT1-MMP expression in DU-145, PC-3, and PC-3N cells and in PC3-N cells using chromatin immunoprecipitation analysis and silencing RNA. …

    arizona-thes Repository record

  5. Nuclear receptor co-repressor functions in prostate cancer; in vitro, in vivo and in silico approaches

    Battaglia, SebastianoUniversity of Birmingham2010

    … over non-malignant cells RWPE-1 while malignant PC-3 cells retain their proliferative ability. The Nuclear Receptor Co-Repressor 1 (NCOR1) complexes with Histone Deacetylases (HDACs) to repress the action of unliganded NRs, hence, inhibiting their transcriptional and phenotypical effects. NCOR1 …

    birmingham Repository record

  6. Untersuchungen zur Kombinationswirkung von Valproat und Bestrahlung in Bezug auf klonogenes Überleben, Apoptose, Polyploidie und chromosomale Instabilität in Prostatakarzinom- und Prostatahyperplasie-Zelllinien

    Friedrich, Christiane2012

    … Wirkung bei den Prostata-Karzinom-Zelllinien (PC-3 und DU-145) und keine Radiosensibilisierung bei den Prostata-Hyperplasie-Zelllinien (BPH-1, PTN-2). Die Ursache dieses Effektes konnte nicht abschließend geklärt werden. Die DU-145-Zellen zeigten eine Erhöhung der Apoptose-Rate durch diese …

    goettingen Repository record

  7. “Differential regulation of PTHrP gene expression by 1,25(OH)2D3 in prostate cancer cell lines”

    Veronica Alejandra Tovar SepulvedaThe University of Texas Medical Branch2005

    … prostate cancer cell lines LNCaP, C4-2, and PC-3. These cell lines represent early to advanced stages of prostate cancer, since LNCaP cells are weakly metastatic, androgen receptor (AR)-positive and androgen-responsive cells, C4-2 cells are AR-positive and androgen-independent LNCaP variants, …

    utmb Repository record

  8. Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists

    Vaithianathan, Soundarya2021

    … the proliferation of prostate cancer cell lines, PC-3 and M12. A new lead compound has been identified which showed micromolar level of inhibition to PC-3 cell line proliferation as well as calcium mobilization. These studies are the beginning of a thorough analysis of the CCR5 receptor antagonist …

    vcu Repository record

  9. The <em>In Vitro</em> Cellular Uptake and Physiochemical Properties of Tocotrienols.

    Zuo, Tianming2003

    … uptake and growth inhibition of tocotrienols in PC-3 cells. The second part is a study of the physiochemical properties of Vitamin E.</p><p>In the cellular study our results suggested that position 5 of chroman head and side-chain are very important in determining the uptake of tocotrienols and …

    etsu Repository record

  10. Inhibition des 26s Proteasoms : molekularer Mechanismus der Hyperthermie in Prostatakarzinomzellen?

    Rieß, Katrin

    … beeinflußt. <br>Humane PK- (PC-3, LNCaP, DU-145), Glioblastom- (A172), Melanom- (A375) und Bronchialkarzinomzellen (A549) und murine PK-Zellen (TRAMP C1, TRAMP C2) wurden hyperthermiert (1 Stunde, 44 Grad C, +/- 20Gy, +/- Cycloheximid). Im zellulären Proteinextrakt wurde die …

    freiburg-diss Repository record

  11. Investigation of the effect of microwave irradiation (2.45 GHz) on biological systems at constant bulk temperature

    MAZINANI, SINABrock University2019

    … acid) into the cell membrane of PC-3 (human prostate cancer) cells was facilitated by microwave treatment at constant temperature. Also, microwave treatment while non-apoptotic, significantly increased the rate of reduction of MTT …

    brock Repository record

  12. Isolation and functional analysis of differentially expressed genes in human prostate cancer

    Grzmil, Michal2012

    … Genexpression in menschlichen Prostatakarzinom PC-3 Zellen zu reduzieren, was in einer signifikanten Suppression der Zellinvasion und Proliferation sowie in einer Erhöhung der Zellapoptose von PC-3 Zellen resultierte. Weiterhin wurde gezeigt, dass eine direkte Korrelation zwischen der …

    goettingen Repository record

  13. Probing Proteasome Inhibition By Metal Copmplexes As A New Route For Anticancer Therapy

    Tomco, Dajena2014

    … properties against the growth of prostate cancer PC-3 cells. It has been demonstrated that apoptosis induction of the PC-3 cells is due to the inhibition activity of the 26S proteasome upon treatment of various concentrations of these metal-based pro-drugs. The antiproliferative effects of these …

    wayne-thes Repository record

  14. Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging

    Kujala, Naresh Gandhi, 1975-University of Missouri--Columbia2009

    … imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific uptake, internalization and receptor blocking of these probes. In vivo investigations in severely compromised immunodeficient (SCID) mice bearing xenografted PC-3 prostate and T47-D …

    missouri Repository record

  15. Effekte der Antiepileptika Carbamazepin und Lamotrigin auf das Prostatakarzinom

    Sürig, Stefan2012

    … der Vitalität und Proliferation in der LNCaP und PC-3 Linie. Durch beide Medikamente konnte eine Heraufregulation des ER-B erreicht werden und eine Rektifizierung der IGF-Achse. Die Heraufregulation des ER-B konnte ebenfalls bei der Mammakarziomzelllinie gefunden werden. Mit Carbamazepin und …

    goettingen Repository record

  16. Investigation of the Anti-Proliferative and Pro-Apoptotic Effects of Rosemary (Rosmarinus officinalis) Extract on Androgen Independent Prostate Cancer Cells

    Termini, DeborahBrock University2022

    … stages (castration-resistant prostate cancer- CRPC) is often seen, indicating a need for novel therapeutics that specifically and efficiently target the dysregulated mechanisms in prostate cancer. In some studies, rosemary extract and its polyphenolic constituents have been shown to have …

    brock Repository record

  17. The direct effects of estradiol and several xenoestrogens on cell numbers of early- vs. late-stage prostate cancer cells

    Koong, Luke YThe University of Texas Medical Branch at Galveston2016

    … than DES at reducing cell numbers of both LAPC-4 early-stage androgen-dependent and PC-3 late-stage androgen-independent prostate cancer cells. Both E2 and DES rapidly (within minutes) activated mitogen-activated protein kinases, generated reactive oxygen species (ROS), induced apoptosis and …

    utmb Repository record

  18. Chemosensory Evaluation of Prostate Cancer Cells

    Martinez, Rebecca L.Virginia Tech2010

    … between prostate cancer cells (DU-145 and PC-3) and non-tumor forming cells from the urinary tract (SVHUC). Specific factors that will be investigated are incubation period and cell population. For all three cell lines, two cell populations of 75,000 and 150,000 cells were cultured and …

    vt Repository record

  19. Assessing bioactivity of a peptide from the skin secretion of the central American red-eyed leaf Frog, Agalychnis callidryas

    Shang, GuanxiongQueen's University Belfast2019

    … However, the peptide had activity against PC-3 and H157 human cancer cell lines at a range of concentrations from 1 to 100 μM. Also, it had a weak inhibitory function on U251MG cancer cells at concentrations from 50 to 100 μM. QUB-2428 displayed obvious inhibitory activity against PC-3 …

    qu-belfast Repository record

  20. An analysis of the periodicity of the cell cycle and apoptotic regulatory proteins in prostate xenografts using anova and cosinor methods

    Hosdaghian, Aleen

    … The ALVA-3 1 (androgen-independent) and PC-3 (androgen-independent) prostate cancer cell lines were grown in vivo, as a subcutaneous xenograft in mice and measured at seven different Hours After Light Onset (HALO). Measurements were taken at 3, 7, 10, 13, 17, 20 and 23 HALO, which is …

    njit Repository record

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