Evolution of the mysRS element in the genome of rodent species

<p>Retrotransposons are a type of transposable element in which DNA copies are produced via an RNA intermediate and integrate into new chromosomal sites continually contributing to the dynamics of genomes. While sequencing the mys element among the Cricetidae family of rodents, we identified a previously uncharacterized element in the genome of the Mexican volcano mouse that we refer to as mys-related sequence (mysRS). This investigation provides a unique opportunity to contrast the evolution of the two retrotransposon families apparently restricted to a specific taxonomic group of rodents. By analyzing the genomes of various cricetid rodents, our results provide evidence that the mysRS element originated in either an ancestor of the Neotominae subfamily or the Reithrodontomini tribe of rodents, which diverged roughly nine million years ago, and predates the appearance of the mys element.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Open Access Thesis

Discipline thesis:degree_discipline

Biology

Year dc:date.available

2016

Author dc:creator

• Scott, Megan M

Contributors dc:contributor

• David Kass
• Katherine Greenwald
• Lynne Shetron-Rama

• Cricetidae
• mys
• mysRS
• Retrotransposons
• Biology
• Life Sciences

Repository record dc:identifier

https://commons.emich.edu/theses/786

OAI identifier oai:identifier

oai:commons.emich.edu:theses-2163