Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents

<p>This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, <em>et. al</em>. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-<em>d</em>]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-<em>d</em>]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.</p>

Name thesis:degree_name

MS

Level thesis:degree_level

One-year Embargo

Discipline thesis:degree_discipline

Medicinal Chemistry

Year dc:date.available

2017

Author dc:creator

• Yang, Si

Contributors dc:contributor

• Aleem Gangjee
• Patrick Flaherty
• Marc W. Harrold

• Anticancer
• Antifolate
• Pyrrolo[2
• 3-d]pyrimidines
• chemotherapy
• GARFTase inhibitors
• Folate Receptor
• PCFT
• Reduced Folate Carrier
• de novo purine synthesis
• Medicinal and Pharmaceutical Chemistry
• Natural Products Chemistry and Pharmacognosy
• Nucleic Acids, Nucleotides, and Nucleosides
• Pharmaceutics and Drug Design

Language dc:language

English

Repository record dc:identifier

https://dsc.duq.edu/etd/225

OAI identifier oai:identifier

oai:dsc.duq.edu:etd-1231