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Showing 1 to 20 of 778 for “"Anticancer"”.
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Anticancer activity of ceratotheca triloba
Submitted in complete fulfillment for the Degree of Doctorate of Philosophy in Biotechnology, Durban University of Technology, Durban, South Africa, 2016.
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Anticancer Potential of Soy Peptides
… with lowering cancer risk. However, the anticancer potential and mechanism of soy peptides have not been fully understood. The objective of this research was to evaluate the anticancer potential of soy peptides and to elucidate the role of lunasin on an established cancer cell line. The …
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Modified taxols as anticancer agents
Modifications of the potent anticancer agent taxol were carried out in order to gain an understanding of the chemical reactivity of the drug and the factors which contribute to its biological activity. The C-2' and/or the C-7 hydroxyl groups of taxol were substituted with acetyl, ßalanyl, silyl, …
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Comparison of phenanthriplatin, a novel monofunctional platinum based anticancer drug candidate, with cisplatin, a classic bifunctional anticancer drug
… responsible for removal of platinum-based anticancer drugs. In this study, 146 bp duplexes were prepared containing either a site-specific cisdiammineplatinum( Il)-DNA intrastrand d(GpG) cross-link or a cisdiamminephenanthridinechloroplatinum( Il)-DNA dG adduct. Comparison of the repair …
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Liposome drug delivery systems for anticancer agents
… of liposome formulation of an amphiphilic anticancer peptide using the ANTS/DPX leakage assay. The effects of lipid composition on the liposomes' resistance to an amphiphilic cyclic peptide c[KS.S.S.KWL W] were studied by the ANTS/DPX leakage assay. One or more unsaturated acyl chains in …
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Anticancer and antibiotic leads from marine organis
… As our efforts towards the discovery of anticancer and antibiotic drug leads from marine organisms, modifications of anticancer drug candidate kahalalide F, isolations of new peptides from the mollusk, Elysia rufescens and anticancer drug leads from the NCI repository, as well as chemical …
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South African marine compounds as anticancer agents
Oesophageal cancer is the most common cause of cancer related deaths among black males in South Africa. Currently there are very limited treatment options, and patients have a very poor prognosis, due in part to the late stage at which this cancer is usually detected. In this thesis we describe the …
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Cellular responses to platinum-based anticancer drugs
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Synthesis of Novel CYP1 Activated Heterocyclic Anticancer Prodrugs
… In conclusion, DMU 10212, a novel CYP1 activated anticancer prodrug with selective high toxicity towards tumour cells has been identified.
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Anticancer activity of Lovage (Levisticum officinale Koch) extracts
… (Lovage), and to assess whether they had any anticancer properties. Two human cancer cell lines were used in the anticancer screening assays (THP-1, a leukaemia cell line and MCF7, epithelial breast cancer cells) and a modified normal cell line (PNT2A, prostate epithelial cells). The n-hexane, …
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The anticancer potential of CITme, a quinoline derivative
3-[3-(7-chloro-quinolin-4-yl amino) phenyl]-1-(4-methoxy-phenyl) prop-2-enone citrate “CITme” is a substituted quinoline derivative, synthesized as a potential antitumour agent. The aim of this study was to investigate CITme with regard to antitumour activity, toxicity and pharmacokinetics. In …
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Silver (I) Complexes as Antimicrobial and Anticancer Drugs
… (9-acaH) and imidazoles as new antimicrobial and anticancer drugs. The detailed synthesis of silver(I)-containing carboxylates, such as polymeric [Ag2(9-aca)2]n and [Ag2(9-aca)2(DMSO)2]n, and the ammoniacontaining complex, [Ag4(9-aca)4(NH3)2], are provided along with imidazole derivatives, such as …
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Thiazolidinone-isatin hybrids as multi-target anticancer agents
During the three years of PhD two main projects have been carried out. The projects were focused on the design, synthesis, and characterization of small molecules with antitumoral activity. Cancer is one of major causes of death in the world and, considering its multi-factorial origin it could be …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Development and Evaluation of Organometallic Anticancer Drug Candidates
There is an urgent need to find novel anticancer therapeutics with different mechanisms of action than platinum-containing drugs, particularly for patients who relapse after having been initially treated with a platinum-containing chemotherapy regimen. This chemoresistance phenomena, along with the …
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Probing Non-Canonical DNA Structures With Anticancer Drugs
T:G mismatched base pair is associated with many genetic mutations. Understanding its biological consequences can be aided by studying the structural perturbation of DNA caused by T:G base pair and by specific probing of the mismatch using small molecular ligands. We have shown that AR-1-144, a …
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Chemical diversification and anticancer activity of natural products
Made available in DSpace on 2014-01-16T18:25:34Z (GMT). No. of bitstreams: 3 Karen_Morrison.pdf: 14532423 bytes, checksum: af6a40d935f8782447ddd84ef12a94ae (MD5) Morrison_Karen.docx: 44256739 bytes, checksum: 6353cc66b66320dd9c663bda8c68747b (MD5) license.txt: 4063 bytes, checksum: …
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