This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, et. al. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.
","abstract_html":"<p>This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, <em>et. al</em>. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-<em>d</em>]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-<em>d</em>]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.</p>","abstract_has_math":false,"creators":["Yang, Si"],"institution":null,"degree_name":"MS","degree_level":"One-year Embargo","degree_discipline":"Medicinal Chemistry","degree_department":null,"school":null,"contributors":["Aleem Gangjee","Patrick Flaherty","Marc W. Harrold"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2017,"date_issued":"2017-12-01T08:00:00Z","date_published":"2017-12-01T08:00:00Z","updated_at":"2026-07-24T02:09:13Z","subjects":["Anticancer","Antifolate","Pyrrolo[2","3-d]pyrimidines","chemotherapy","GARFTase inhibitors","Folate Receptor","PCFT","Reduced Folate Carrier","de novo purine synthesis","Medicinal and Pharmaceutical Chemistry","Natural Products Chemistry and Pharmacognosy","Nucleic Acids, Nucleotides, and Nucleosides","Pharmaceutics and Drug Design"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://dsc.duq.edu/etd/225","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Aleem Gangjee","Patrick Flaherty","Marc W. Harrold"]},{"key":"dc:creator","label":"Author","values":["Yang, Si"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2018-12-10T08:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Medicinal Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["One-year Embargo"]},{"key":"thesis:degree_name","label":"Degree Name","values":["MS"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Anticancer","Antifolate","Pyrrolo[2","3-d]pyrimidines","chemotherapy","GARFTase inhibitors","Folate Receptor","PCFT","Reduced Folate Carrier","de novo purine synthesis","Medicinal and Pharmaceutical Chemistry","Natural Products Chemistry and Pharmacognosy","Nucleic Acids, Nucleotides, and Nucleosides","Pharmaceutics and Drug Design"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["English"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://dsc.duq.edu/etd/225"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, et. al. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.
"]},{"key":"dc:title","label":"Title","values":["Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents"]}]}],"canonical_facts":{"dc:contributor":["Aleem Gangjee","Patrick Flaherty","Marc W. Harrold"],"dc:creator":["Yang, Si"],"dc:date.available":["2018-12-10T08:00:00Z"],"dc:description.abstract":["This thesis mainly focuses on the introduction of the background and work have been done in the areas of antifolates development, such as folate function, its three uptake mechanisms inside human cells, antifolates’ role in chemotherapy, et. al. In addition, the Structure-Activity-Relationship design rationale for the series of antifolates will also be discussed. Nevertheless, the details of synthesizing these pyrrolo[2,3-d]pyrimidines as potential antifolates have been described, including chemistry reviews on the pyrrolo[2,3-d]pyrimidine scaffold, and the challenges encountered and the solutions how to solve or improve in order to achieve better yield.
"],"dc:identifier":["https://dsc.duq.edu/etd/225"],"dc:language":["English"],"dc:subject":["Anticancer","Antifolate","Pyrrolo[2","3-d]pyrimidines","chemotherapy","GARFTase inhibitors","Folate Receptor","PCFT","Reduced Folate Carrier","de novo purine synthesis","Medicinal and Pharmaceutical Chemistry","Natural Products Chemistry and Pharmacognosy","Nucleic Acids, Nucleotides, and Nucleosides","Pharmaceutics and Drug Design"],"dc:title":["Synthesis of 2,4,6-Substituted Pyrrolo[2,3-d]pyrimidines as Potential Anticancer Agents"],"thesis:degree_discipline":["Medicinal Chemistry"],"thesis:degree_level":["One-year Embargo"],"thesis:degree_name":["MS"]},"updated_at":"2026-07-24T02:09:13Z"}