Function of two closely related fibroblast growth factors in early mesoderm development of <em>Drosophila melanogaster</em>

Thisbe (Ths) and Pyramus (Pyr) are the ligands for the Fibroblast-Growth-Factor (FGF)receptor Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during organogenesis, loss and gain of function studies were performed. In an approach of functional analysis, a single mutant allele of ths was generated, ths759, for comparison of the single mutant conditions of ths and the null mesodermal cells to migrate and differentiate in a precise pattern.

Name dc:type.qualificationname

Doctor of Philosophy

Level dc:type.qualificationlevel

Doctoral Thesis

Grantor dc:publisher.institution

University of Dundee

Year dc:date.issued

2009

Author dc:creator

• Klingseisen, Anna

Advisor dc:contributor.advisor

• Muller, Hans-Arno

• Gastrulation
• Mesoderm migration
• Heart development
• Fibroblast growth factor

Language dc:language

eng

Identifier

oai:discovery.dundee.ac.uk:studenttheses/07ea3e0f-9fd7-4123-90fb-8f552797bec5

OAI identifier oai:identifier

oai:discovery.dundee.ac.uk:studenttheses/07ea3e0f-9fd7-4123-90fb-8f552797bec5