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Showing 1 to 20 of 118 for “"Gastrulation"”.
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Regulation of Zebrafish Gastrulation Movements by slb/wnt11
During zebrafish gastrulation, highly coordinated cellular rearrangements lead to the formation of the three germ layers, ectoderm, mesoderm and endoderm. Recent studies have identified silberblick (slb/wnt11) as a key molecule that regulates gastrulation movement through a conserved pathway, which …
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A Role for Dynamin-Dependent Endocytosis During Drosophila Gastrulation
<p>Gastrulation, a process conserved among many higher organisms, is the directed migration of cells into layers that will establish various tissues targeted to become anatomical structures. This process is accomplished through another conserved morphogenetic event, known as cell intercalation. …
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Cellular Morphodynamics Reveals Divergent Mechanisms of Gastrulation in Insects
… of which the earliest occurrence drives mesoderm gastrulation in a wide variety of organisms. In both the fly Drosophila melanogaster and the beetle Tribolium castaneum, the mesoderm is specified ventrally by conserved genetic factors as an epithelial sheet that buckles inwards, forming a tube …
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Bovine Pre-gastrulation Development and the role Of Rauber's Layer
… blastocyst hatching at Day 8 and the onset of gastrulation after Day 14. Post hatching, the bovine embryo develops a morphological architecture which is very different to the mouse, with a flat epiblast and the loss of the polar trophoblast, known as Rauber’s layer. In mice, the polar …
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Variabilität molekularer axialer Differenzierung am Beginn der Gastrulation beim Kaninchen
… Differenzierung der Körperachsen in der frühen Gastrulationsphase des Säugerembryos beteiligt sind. Variabilität und Stabilität der molekularen Blaupause , die der morphologischen Entwicklung zu Grunde liegt, wurden exemplarisch an im Hypoblast exprimierten Schlüsselgenen der frühen …
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Pumilio Regulates the Epithelial-Mesenchymal Transition and Gastrulation During Zebrafish Development
… organizer structures during the first steps of gastrulation. Gastrulation events necessitate both proper patterns of gene signaling and cell motility, as gained by epithelial-to-mesenchymal transitions (EMT), to occur. In pum1 morphants, both the presentation of wild-type signaling gradients and …
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Imaging Drosophila embryo gastrulation to identify stress fields and biomechanical feedback
Several potential mechanisms of mechanical coordination of the constriction of the cell apices in groups of cells have been proposed. Our previous computational studies have shown a connection between tensile mechanical feedback and Cellular Constriction Chains (CCCs) that propagate during the …
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Investigations of collective cell movement during gastrulation in the chick embryo
During gastrulation in the chicken embryo, the mesoderm and endoderm progenitors migrate in a collective manner. They ingress through the primitive streak and follow routes that reflect their developmental fate. Despite its importance for the formation of the body plan, the mechanisms that define …
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Rab35 Centered Membrane Trafficking Pathway Directs Apical Constriction During Drosophila Gastrulation
… shape. During <em>Drosophila melanogaster</em>gastrulation, the invagination of the prospective mesoderm is driven by the pulsed constriction of apical surfaces. Here, we address the mechanisms by which the irreversibility of pulsed events is achieved while also permitting uniform epithelial …
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RNA helicase MOV10 is essential for gastrulation and normal CNS development
… mRNAs in one-cell stage embryos results in a gastrulation defect at Stage 10 of Xenopus embryonic development. RNA sequencing of embryos from Stage 10.5 of the Mov10 knockout shows an increase in mRNAs levels consistent with a miRNA-mediated role of Mov10 possibly at the Maternal to Zygotic …
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Nodal organized cell dynamics for building tissue shapes in vertebrate gastrulation
… mesoderm and controls cell movement during gastrulation. How Nodal alters cell dynamics and mechanics is not well understood. To explore Nodal’s morphogenetic role in detail, we injected Nodal-related-2 (ndr2, cyclops) mRNA into one blastomere at the 128-cell stage animal pole of the …
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The Molecular Basis of Tissue Elasticity and Force Balance During Drosophila Gastrulation
… domains remain unknown. To begin, I studied gastrulation in a genetic background where basal membranes never form and cells remain open to the yolk sack throughout the course of VF formation. Strikingly, the VF is still capable of forming in this background. I extensively characterize this …
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Identification of proteins controlling gastrulation movements by a proteomic approach in zebrafish
During vertebrate gastrulation, a well-orchestrated series of cell movements leads to the formation of the three germ layers: ectoderm, mesoderm and endoderm. In zebrafish, a model organism for vertebrate development, the mesendodermal progenitor cells separate from the ectodermal cells and migrate …
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Multi-omics characterisation of mouse gastrulation and organogenesis at single-cell resolution
… occurs. These changes are essential for gastrulation, the process by which all three germ layers - ectoderm, mesoderm, and endoderm - are specified. Recent advances in single-cell sequencing technologies have allowed the characterisation of the transcriptional and epigenetic changes …
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The role of yolk syncytial layer and blastoderm movements during gastrulation in zebrafish
During gastrulation, a set of highly coordinated morphogenetic movements creates the shape and internal organization of the embryo. In teleostean fishes, these morphogenetic movements involve not only the embryonic progenitor cells (deep cells) but also two extra-embryonic tissues: an outer sheet …
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Investigation of cell movement and the associated cytoskeleton during chick gastrulation and somitogenesis
… changes to the cytoskeleton. During avian gastrulation, cells ingress through the primitive streak. Previous characterisation of microtubule organisation during this process revealed the distribution of cells with polarised and radial arrays across different regions of the embryo. …
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Morphogenetic forces planar polarize LGN/Pins in the embryonic head during Drosophila gastrulation
During embryonic development, epithelial tissues grow and undergo dramatic changes to adopt complex shapes. Coordinated cell behaviors, including oriented cell divisions are crucial to the proper development of epithelia. How forces are transmitted across the developing embryo and how these forces …
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The roles of T and Tbx6 during gastrulation and determination of left/right asymmetry
T and Tbx6 belong to the T-box family of transcription factors. T homozygous null mutants lack posterior somites after the seventh pair, have no distinguishable notochord, have a convoluted neural tube and die at E.10.5. In this study we investigate the phenotype of a dominant negative allele of T, …
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TET1 AND TRANSCRIPTION FACTOR REGULATION OF LINEAGE SPECIFICATION DURING MOUSE GASTRULATION AND EARLY ORGANOGENESIS
Gastrulation and early organogenesis are overlapping events between Embryonic day (E) 6.25 and E9.5 in mouse that involve the specification of pluripotent cells into the lineage- and tissue-specific precursors of the adult organism. The dozens of cell types that arise during this period are defined …
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The effects of BMP4 on different in vitro models for mouse gastrulation and neural induction
… several key developmental processes, including gastrulation and neural induction. Gastrulation is an event that changes the topology of the embryo, organising a single layer or ball of cells into the three primordial germ layers: the mesoderm, endoderm and ectoderm. In the mouse embryo, …
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