Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Mesoderm"”.
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Mesoderm diversification during mouse embryonic development
… and express genes characteristic of other mesodermal lineages. Although single-cell transcriptomics unveils the molecular programs defining each cell type, studying gene expression is not enough if we want to highlight the regulatory events behind cell type diversification. Therefore, in …
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Role of multicellular organisation in mesoderm differentiation
… cell shape associated with differentiation into mesodermal and endodermal derivatives. Primitive streak formation and gastrulation are orchestrated by Nodal, BMP, Wnt and Fgf signalling pathway activity. However, it is unclear if and how changes in tissue architecture influence the …
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Investigating the role of cell cycle regulators in mesoderm specification
Mesoderm is one of the three primary germ layers from which the cardiovascular system, muscle and bone originate and derivatives of the mesoderm lineage are affected in a number of pathologies. Therefore, understanding the mechanisms regulating formation of mesoderm is interesting for a diversity …
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Investigating the role of Notch signalling during mesoderm development and cell proliferation
… studied, the role of Notch signalling during mesodermal specification remains unclear. In addition, novel insight, which revealed that human Notch1 forms nuclear biomolecular condensates, raised questions regarding the effect of physical interactions between Notch1 proteins and target gene RNA …
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A genetic test of the role of activins in mouse mesoderm formation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1995.
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A genetic analysis of germ cell migration and gonadal mesoderm development in drosophila
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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C-Rel Is A Transcriptional Target of Mesoderm Inducer In Xenopus Like 1 (Mixl1)
<p>MIXL1, an evolutionarily conserved, paired-type homeobox transcription factor induced by BMP4/TGFb signaling, is a critical regulator of embryonic and adult hematopoiesis. Several lines of evidence implicate MIXL1 in hematopoietic transformation: (i) Aberrant MIXL1 expression is seen in human …
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Eomes Directs the Formation of Spatially and Functionally Diverse Extra-Embryonic Mesoderm Derived Tissues
During mouse embryonic development, the first mesodermal cells to originate at the posterior primitive streak will give rise to the extra-embryonic mesoderm (ExEM). These cells will contribute to key tissues supporting the development of the embryo, including the amnion, chorion, yolk-sac, and …
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The evolution of somitogenesis: Mechanisms of paraxial mesoderm elongation in zebrafish and other vertebrates
… elongation and segmentation of the paraxial mesoderm to form somites. Although the segmentation aspect of this has been widely studied, the elongation aspect is not well understood. Posterior growth is widely assumed to be the main driver, but there is very little evidence for this – …
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Function of two closely related fibroblast growth factors in early mesoderm development of <em>Drosophila melanogaster</em>
… Heartless (Htl), which is expressed in all mesodermal cells during gastrulation. To understand how these two FGFs orchestrate mesoderm spreading in gastrulation and mesoderm differentiation during organogenesis, loss and gain of function studies were performed. In an approach of functional …
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Genetic dissection of germ cell migration and the distinction between gonadal mesoderm and fat body development in drosophila
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1998.
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Fibronectin and Laminin, extracellular matrix proteins, have an origin in mesoderm tissue and promote anterior neural tube closure in zebrafish
… from several laboratories has demonstrated that mesoderm is required for anterior neural tube closure in mice and zebrafish. In all vertebrates, there is an extracellular matrix between the mesoderm and the developing neural tube. I hypothesized Fibronectin (Fn) and Laminin (Lam), extracellular …
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Identification and characterization of genetic interactors of the Rho Guanine-nucleotide exchange factor Pebble in <em>Drosophila</em>
… encodes a Rho GEF required for the migration of mesoderm cells during Drosophila gastrulation. The spreading of mesoderm cells is controlled by the FGF signalling pathway acting through the FGF receptor Heartless (Htl). Pbl represents an important downstream component of this FGF pathway and …
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The role of pax genes in vertebrate segmentation
… in particular are associated with the paraxial mesoderm, especially the development of the myogenic lineage. However, recent studies have suggested that Pax3 and Pax7 may have earlier, morphogenetic roles in the segementation of the paraxial mesoderm. Here we examine the expression of Pax3 and …
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Cellular Morphodynamics Reveals Divergent Mechanisms of Gastrulation in Insects
… of which the earliest occurrence drives mesoderm gastrulation in a wide variety of organisms. In both the fly Drosophila melanogaster and the beetle Tribolium castaneum, the mesoderm is specified ventrally by conserved genetic factors as an epithelial sheet that buckles inwards, forming a …
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Control of heart development in the Mexican axolotl (Ambystoma mexicanum).
… However, the processes whereby the heart-forming mesoderm is induced, and the later mechanisms controlling the differentiation and morphogenesis of the heart are only poorly understood for any system. An important model system for studying heart induction and differentiation is the cardiac-lethal …
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Molecular Basis of Vertebrate Embryonic Migration
… where the three primordial layers, the ectoderm, mesoderm and the endoderm are one on top of the other. The three germ layers will go on to form all the tissues and organs of the embryo. For example, the ectoderm will give rise to epidermis and the nervous system; the mesoderm to muscles, the …
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Germ lineage specification from a pluripotent primitive ectoderm-like substrate: a role for cell-cell contacts.
… ectoderm cells form the three germ lineages, mesoderm, ectoderm and endoderm under the control of complex signalling and environmental cues. This process can be modelled using embryonic stem cells, which have proven to respond to embryologically relevant signals during in vitro differentiation …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… ingress through the primitive streak and form mesoderm. To better understand the molecular pathways of EMT during this developmental transition, we developed a model system utilizing mouse embryonic stem: ES) cells. We show that EMT occurs during ES cell differentiation and is dependent on the …
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