The role of midgut serine proteases in Aedes aegypti vector competence

Numerous gut-associated viruses utilize host proteolytic enzymes to facilitate enhancement of infection. Similarly, arboviruses infecting the invertebrate host (vector) through the alimentary tract may exploit serine proteases in the midgut to enhance vector infection. Recent genetic and biochemical experiments have demonstrated that dengue virus type 2 (DENV-2) may require proteolytic processing by midgut trypsins to efficiently infect Aedes aegypti. These results suggest midgut serine proteases may influence A. aegypti vector competence. The requirement of serine proteases in DENV-2 infection of the vector provides unique targets for development of novel control strategies through approaches such as transmission blocking vaccines.

Name thesis:degree_name

Doctor of Philosophy (Ph.D.)

Level thesis:degree_level

Doctoral

Discipline thesis:degree_discipline

Microbiology, Immunology, and Pathology

Grantor dc:publisher

Colorado State University. Libraries

Year dc:date.issued

2007

Authors dc:creator

• Brackney, Douglas Eugene, author
• Olson, Kenneth E., advisor

• Aedes aegypti
• serine proteases
• vector competence
• organismal biology
• parasitology
• virology
• entomology

Statement dc:rights

• Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright.

Language dc:language.iso

eng, English

Identifier URI

https://doi.org/10.25675/3.018484

OAI identifier oai:identifier

oai:mountainscholar.org:10217/237597