Sensory Primary Cilium is a Distinct Signaling Compartment

<p>The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance of the primary cilium. As an important organelle involved in sensory functions and signal transductions, we encompass methodology for measuring cilia signaling along with a study of pH sensing function and cAMP signaling dynamics in the cilium. Defects in the structure of cilia or protein complexes located in the primary cilia cause a variety of diseases. With increasing the knowledge of ciliary biology, we can strategize approaches to repair defective cilia. Here we try to contribute to understanding the complex dynamic pathways of the cilia and point to potential pathways in regulating ciliary structure and function.</p>

Name thesis:degree_name

Doctor of Philosophy (PhD)

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Pharmaceutical Sciences

Year dc:date.available

2019

Author dc:creator

• Sherpa, Rinzhin Tshering

Contributors dc:contributor

• Surya M. Nauli
• Reza Mehvar
• Rennolds Ostrom
• Marco Bisoffi

• Biology
• Cell Biology
• Molecular Biology

Repository record dc:identifier

https://digitalcommons.chapman.edu/pharmaceutical_sciences_dissertations/1

OAI identifier oai:identifier

oai:digitalcommons.chapman.edu:pharmaceutical_sciences_dissertations-1000