Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Apical cell"”.
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Opposing Crosstalk between Rho1 and Cdc42 in Epithelial Morphogenesis
Epithelial cells line all surfaces of the body exposed to external environments where they perform critical roles for maintaining homeostasis. In addition, epithelial cells are implicated in several disease processes and are the most common cell type implicated in cancer. Therefore, understanding …
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Automatic Cell Tracking For Studying Large Epithelial Sheets Of Cells And Its Application To Chicken Gastrulation
… vortical flows that involve an order of >200,000 cells. During this self-organised process individual epithelial cells are migrating in a highly coordinated manner. The cell behaviours driving the flows and migration are unknown due to the lack of high resolution time lapse sequences showing each …
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Organizing morphogenesis: Mechanisms of actomyosin patterning by RhoGTPase signaling
… is an astonishing orchestration of molecules, cells and tissues, of signaling and mechanics, across space and time. How are its components choreographed across scales? This thesis investigates this question in the context of Drosophila ventral furrow formation, a well-established, simple model …
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Sensory Primary Cilium is a Distinct Signaling Compartment
<p>The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia …
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Force-induced calcium concentration change and focal adhesion translocation : effects of force amplitude and frequency
Vascular endothelial cells rapidly sense and transduce external forces into biological signals through a process known as mechanotransduction. Numerous biological processes are involved in mechanotransduction, including calcium signaling and activation of focal adhesion sites, but little is known …
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Development of Three-Dimensional Super-Resolution Imaging Using a Double-Helix Point Spread Function
… samples (e.g. in the nucleus and on the apical cell surface). Application of the DHPSF for SPT in eukaryotic cells are presented; tracking the motion of T-cell membrane proteins on the apical surface and components of the chromosome remodelling complex in the nucleus of embryonic stem …
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The role of brown algal cell walls in morphogenesis and development
… changes in the structure and mechanics of the cell wall. Despite taking different evolutionary paths, land plants and some brown algae exhibit great developmental and morphological similarities. In two brown algal model systems: the Sargassum muticum apex and the Fucus serratus embryo, I have …
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The CFTR Folding Pathway: Implications for the Identification and Development of CF Therapeutics
… important for Cl- conductance at the apical cell membrane. Loss-of-function of CFTR leads to Cystic Fibrosis (CF), a fatal genetic disease affecting 70,000 people worldwide. There are hundreds of CF causing mutations with the most common being ΔF508, present in at least one allele in …
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Biophysical and gene expression change in living cells by force-induced mechanotransduction
… in regulating the physiologic functions of cells and tissues. The importance of engineering principles in studying the biological behavior of cells is no longer in question. Instead, much research is now focused on how mechanical forces are transduced into biochemical activities and …
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Morphogenesis in the moss physcomitrella patens
… and switch to caulonema after one or two cell cycles. The early cell divisions of bud formation were found to follow a distinct pattern, which was upset by high concentrations of cytokinin and lanthanum. The response of caulonema apical cells to polarotropic light was recorded and compared …
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COMPARATIVE ULTRASTRUCTURE OF APICAL CELLS AND DERIVATIVES IN BRYOPHYTES, WITH SPECIAL REFERENCE TO PLASMODESMATA
This study focused on the primary cell wall constituents and plasmodesmata (PD) density in three mosses and four liverwort apical cells (AC) and immediate derivatives. The three mosses have tetrahedral apical cells and the liverworts possess tetrahedral, hemidiscoid and lenticular AC geometries. …