The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance of the primary cilium. As an important organelle involved in sensory functions and signal transductions, we encompass methodology for measuring cilia signaling along with a study of pH sensing function and cAMP signaling dynamics in the cilium. Defects in the structure of cilia or protein complexes located in the primary cilia cause a variety of diseases. With increasing the knowledge of ciliary biology, we can strategize approaches to repair defective cilia. Here we try to contribute to understanding the complex dynamic pathways of the cilia and point to potential pathways in regulating ciliary structure and function.
","abstract_html":"<p>The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance of the primary cilium. As an important organelle involved in sensory functions and signal transductions, we encompass methodology for measuring cilia signaling along with a study of pH sensing function and cAMP signaling dynamics in the cilium. Defects in the structure of cilia or protein complexes located in the primary cilia cause a variety of diseases. With increasing the knowledge of ciliary biology, we can strategize approaches to repair defective cilia. Here we try to contribute to understanding the complex dynamic pathways of the cilia and point to potential pathways in regulating ciliary structure and function.</p>","abstract_has_math":false,"creators":["Sherpa, Rinzhin Tshering"],"institution":null,"degree_name":"Doctor of Philosophy (PhD)","degree_level":"Dissertation","degree_discipline":"Pharmaceutical Sciences","degree_department":null,"school":null,"contributors":["Surya M. Nauli","Reza Mehvar","Rennolds Ostrom","Marco Bisoffi"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2019,"date_issued":"2019-08-01T07:00:00Z","date_published":"2019-08-01T07:00:00Z","updated_at":"2026-07-24T01:38:00Z","subjects":["Biology","Cell Biology","Molecular Biology"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://digitalcommons.chapman.edu/pharmaceutical_sciences_dissertations/1","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Surya M. Nauli","Reza Mehvar","Rennolds Ostrom","Marco Bisoffi"]},{"key":"dc:creator","label":"Author","values":["Sherpa, Rinzhin Tshering"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2021-08-01T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Pharmaceutical Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Doctor of Philosophy (PhD)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology","Cell Biology","Molecular Biology"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://digitalcommons.chapman.edu/pharmaceutical_sciences_dissertations/1"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance of the primary cilium. As an important organelle involved in sensory functions and signal transductions, we encompass methodology for measuring cilia signaling along with a study of pH sensing function and cAMP signaling dynamics in the cilium. Defects in the structure of cilia or protein complexes located in the primary cilia cause a variety of diseases. With increasing the knowledge of ciliary biology, we can strategize approaches to repair defective cilia. Here we try to contribute to understanding the complex dynamic pathways of the cilia and point to potential pathways in regulating ciliary structure and function.
"]},{"key":"dc:source","label":"Dc Source","values":["Sherpa RT. Sensory Primary Cilium is a Distinct Signaling Compartment. [dissertation]. Irvine, CA: Chapman University; 2019. https://doi.org/10.36837/chapman.000086"]},{"key":"dc:title","label":"Title","values":["Sensory Primary Cilium is a Distinct Signaling Compartment"]}]}],"canonical_facts":{"dc:contributor":["Surya M. Nauli","Reza Mehvar","Rennolds Ostrom","Marco Bisoffi"],"dc:creator":["Sherpa, Rinzhin Tshering"],"dc:date.available":["2021-08-01T07:00:00Z"],"dc:description.abstract":["The primary cilium is a solitary cellular organelle that protrudes from the apical cell membrane. Findings on cilia-dependent mechanosenstation have shown that the primary cilium acts as a transducer of fluid-shear stress into intracellular signaling. Over recent years, studies in primary cilia have intensified after determining a causal relationship between dysfunctional primary cilia and cystic diseases. Along with its mechanosensory function, the primary cilium houses a variety of receptors, ion channels and transporter proteins. Studies in cilia biology have shown that primary cilia are coordinators of signaling pathways such as Hedgehog (Hh), Wnt, and platelet-derived growth factor (PDGF) pathways during development and tissue homeostasis. The primary cilium has been established as a mechano, chemo- and osmosensing unit that transmits extracellular cues to the cell, which supports the importance of the primary cilium. As an important organelle involved in sensory functions and signal transductions, we encompass methodology for measuring cilia signaling along with a study of pH sensing function and cAMP signaling dynamics in the cilium. Defects in the structure of cilia or protein complexes located in the primary cilia cause a variety of diseases. With increasing the knowledge of ciliary biology, we can strategize approaches to repair defective cilia. Here we try to contribute to understanding the complex dynamic pathways of the cilia and point to potential pathways in regulating ciliary structure and function.
"],"dc:identifier":["https://digitalcommons.chapman.edu/pharmaceutical_sciences_dissertations/1"],"dc:source":["Sherpa RT. Sensory Primary Cilium is a Distinct Signaling Compartment. [dissertation]. Irvine, CA: Chapman University; 2019. https://doi.org/10.36837/chapman.000086"],"dc:subject":["Biology","Cell Biology","Molecular Biology"],"dc:title":["Sensory Primary Cilium is a Distinct Signaling Compartment"],"thesis:degree_discipline":["Pharmaceutical Sciences"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Doctor of Philosophy (PhD)"]},"updated_at":"2026-07-24T01:38:00Z"}