Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores

Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.

Grantor dc:publisher.institution

Department of Chemistry

Year dc:date.issued

2012

Author dc:creator

• Nair, Shankari

Advisor dc:contributor.advisor

• Chibale, Kelly

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/9805

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/9805