{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/9805"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/9805","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores","abstract":"Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.","abstract_html":"Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. 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Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents."]},{"key":"dc:title","label":"Title","values":["Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores"]}]}],"canonical_facts":{"dc:contributor.advisor":["Chibale, Kelly"],"dc:creator":["Nair, Shankari"],"dc:date.accessioned":["2014-11-28T09:53:50Z"],"dc:date.available":["2014-11-28T09:53:50Z"],"dc:date.issued":["2012"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["Malaria stills remains one of the leading causes of death in sub-Saharan Africa, with P. falciparum being the most virulent strain of Plasmodium. Due to the emergence of drug resistance, new antimalarial agents are needed to circumvent this. Similarly, in the treatment of cancer, there is an urgent need for the design and development of new antineoplastic agents. This work describes the design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents."],"dc:identifier.uri":["http://hdl.handle.net/11427/9805"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Chemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:22:43Z"}