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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"chromone"”.
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Synthetic studies and biological evaluation of chromone - 3 - carbaldehydes
Chromones are well known naturally occurring heterocyclic compounds with oxygen as a heteroatom. Chromones are also one of the major classes of naturally occurring compounds, and the interest in their chemistry is due to their wide range of their biological activity. In this study, three classes of …
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Synthetic and spectroscopic studies of 6-substituted chromone derivatives
Chromones and chromone derivatives are naturally occurring compounds found in the plant kingdom; for example, baicalein was used as a diuretic and anti-allergic drug in ancient Chinese medicine. A range of chromone-2-carboxylic acids were synthesized from six substituted 2- hydroxyacetophenones. …
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The development of new synthetic methods for chromone and ergochrome construction
… possess useful anti-tumour properties whilst chromones are useful drugs for the treatment of allergic asthma. The aim of the project was to synthesise ergoflavin or an analogue for the first time, and to this end novel synthetic methods for α,β-unsaturated ketones and oxygenated dienes were …
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Novel addition reactions of some benzopyrans
… a rearrangement product, 3-(2-methylprop-l-enyl)chromone. The reaction of 2-cyclopropyl-2-methyl-3- hydroxymethylenechroman-4-one with hydroxylamine yielded 5-(2-hydroxyphenyl)-4-(4-hydroxy-1-methylbut-1-enyl)isoxazole as a major product. These difficulties limited the availability of …
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Studies in Furobenzopyran Chemistry
A series of 3-acyl(thio)chromones has been prepared. These compounds were acetalised with a variety of diols, with p-TsOH catalysis, under azeotropic conditions, to give the corresponding 3-acyl(thio)chromone acetals. A new rearrangement accompanies the formation of acetals from 3-acetyl- or …
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Design and synthesis of potential chrome-based anti-tuberculosis agents
… of TB. In this investigation, two classes of chromone-based compounds were synthesised. Different reactions were exploited to synthesise target compounds. In the first route, a Vilsmeier-Haack reaction was applied to convert the 3,5-disubstituted/unsubstituted 2-hydroxyacetophenones to …
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Synthesis and evaluation of hybrid compounds based on antimalarial and anticancer pharmacophores
… design, synthesis and biological evaluation of chromone-aminoquinoline hybrids as potentially new chemotherapeutic agents.
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Reactions and rearrangements of chroman-4-ones and related compounds
… Conjugate reduction of the corresponding chromone by sodium borohydride in pyridine provides a simple entry to 3-acetyl and 3-aroyl-2-methylchromanones. These dicarbonyl compounds are versatile intermediates and have been used to prepare a range of benzopyrano isoxazoles, pyrazoles. …
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Synthesis of 6-Substitutedchromone-2- Carboxamide derivatives as corrosion inhibitors for metals in acidic medium
… five (5) non-toxic and inexpensive 6-substitutedchromone-2-carboxamides derivatives (Chromone-2-carboxamide, 6-bromochromone-2-carboxamide, 6-chlorochromone-2-carboxamide, 6-methoxychromone-2-carboxamide and 6-nitrochromone-2-carboxamide) were successful synthesized and evaluated as potential …
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Vom Phenol zum Naturstoff : Entwicklung nachhaltiger Mikrowellen-vermittelter SUZUKI-MIYAURA-Kupplungen und Tandem-Reaktionen
… ebenfalls vom Phenol ableitenden Chromanonen, Chromonen und Cumarinen untersucht. Bei diesen Untersuchungen konnte durch die Entwicklung zweier neuer Tandem-Reaktionen ein nachhaltiger und stufenökonomischer Syntheseweg zur Darstellung substituierter Benzo(dihydro)pyrone aufgezeigt werden. …