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Division of Medical Biochemistry
The role of the CCR5 co-receptor conformation in HIV fusion
Abstract
dc:description.abstractThis thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.
Degree
thesis:*- Grantor dc:publisher.institution
- Division of Medical Biochemistry
- Year dc:date.issued
- 2008
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Salo, Alex
- Advisor dc:contributor.advisor
-
- Flanagan, Colleen
Rights
- Language dc:language.iso
- eng
Identifiers
dc:identifier.*- Handle dc:identifier.uri
- http://hdl.handle.net/11427/3150
- OAI identifier oai:identifier
- oai:open.uct.ac.za:11427/3150