The role of the CCR5 co-receptor conformation in HIV fusion
type: CreativeWork
description: This thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.
abstract: This thesis aimed to better define the co-receptor conformation by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.
author: Salo, Alex
language: eng
date published: 2008
date modified: 2026-07-22T22:23:35Z
provider: University of Cape Town
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Division of Medical Biochemistry

PropertyValue
property ID: Handle
value: http://hdl.handle.net/11427/3150