Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"CCR5"”.
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Association Among CCR5 Genotypes, CCR5 Expression, And In Vitro HIV Infection
The single nucleotide polymorphisms (SNPs) in CCR5 (-2459 G>A [promoter], ¿32 deletion polymorphism [open reading frame, ORF]) influences the expression of CCR5 chemokine receptor on human T lymphocytes. CCR5 is a major coreceptor for HIV to bind to the T cell prior to fusion. Individuals have …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
The chemokine receptor CCR5 (CCR5) plays an integral role within the inflammatory network of cells. Importantly, CCR5 is a mediator in several disease states and can be targeted using small molecule antagonists. Within this work, CCR5’s role in prostate cancer and HIV/AIDS has been exploited in …
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Receptor de quimiocina CCR5 e a suscetibilidade ao Lúpus Eritematoso sistêmico
Resumo não disponível.
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Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
… des CC-Chemokin Rezeptors 5 (CCR5) für die Rezeptorregulation untersucht. Es konnte gezeigt werden, daß sowohl für die β-Arrestin-Bindung als auch für die schnelle Rezeptorinternalisierung wenigstens zwei C-terminale Serin-Phosphorylierungsstellen vorhanden sein müssen, wobei …
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The role of the CCR5 co-receptor conformation in HIV fusion
… by determining whether mutants of the CCR5 receptor stabilized in the active conformation were less able to mediate HIV fussion. Eight mutant receptors were generated by site-directed mutagenesis and screened for constitutive activity using intracellutal signaling assays.
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Single Molecule Ligand Binding Studies on CCR5 by Fluorescence Cross-Correlation Spectroscopy
… receptor (GPCR) C-C chemokine receptor 5 (CCR5) is the major co-receptor for HIV-1. CCR5 binds to the viral glycoprotein gp120 allowing HIV particles to infect T cells. Currently, maraviroc is the only Food and Drug Administration (FDA) approved entry inhibitor for HIV-1 but resistance to …
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Sythesis and Biological Screening of a Series of Novel Chemokine Receptor CCR5 Antagonists
The chemokine receptor CCR5 has been implicated in the pathogenesis of cancers and AIDS. A series of novel piperidine derivatives were designed, synthesized, and evaluated as CCR5 antagonists. The ability of the new ligands to inhibit the increment of intracellular calcium level stimulated by …
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Functional consequences of South African mutations of the HIV-1 co-receptor, CCR5
Four mutations of the CCR5 receptor have been identified in the South African population, but the effects of these mutations on CCR5 function and HIV infection are unknown. We have used in vitro methods to assess the ffect of the mutations, Asp2Val, Leu107Phe, Arg225Gln and Arg225stop, on CCR5 …
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Recombinant CXCR4/CCR5 hybrid receptors as tools for studies of HIV-1 receptor usage
The chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… and subsequent interaction, mainly with either CCR5 or CXCR4 co-receptors. Inhibitors, such as Maraviroc, which binds to CCR5 inhibiting entry of CCR5 utilizing viruses (R5 viruses), is currently reserved for salvage therapy in many countries including South Africa. In the course of HIV …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, leukoctyes, memory T cells, and immature dendritic cells. Upon binding to its …
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The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… and chemokines. CC-chemokine receptor 5 (CCR5) is a member of the CC chemokine receptor family of seven transmembrane G protein coupled receptors. CCR5 is expressed in the immune system and is found in monocytes, leukoctyes, memory T cells, and immature dendritic cells. Upon binding to its …
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Distinct Patterns of Ccr5 Versus Alternative Coreceptor Dependence in Non-Natural Host Versus Natural Host Simmian Immunodeficiency Virus Infection
… occurs in the absence of functional coreceptor CCR5, implicating alternative SIV entry pathways in this natural host. In this thesis, I identified host-dependent patterns of SIV coreceptor use that distinguish viral entry in sooty mangabeys from viral entry in rhesus macaques. I cloned and …
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Mechanisms of CCR5 Agonist/Antagonist Inhibition of HIV-1 Entry and In Vitro Selection of Virus Resistant to Maraviroc
… Extensive development of inhibitors that target CCR5, a cellular coreceptor required for viral entry, has resulted in molecules with potent antiviral activity. However, diverse HIV-1 isolates exhibit a wide variation in intrinsic sensitivity to these inhibitors due to factors including the …
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The regulation of CXCR4 and CCR5 expression on human monocytes by Th1 and Th2 cytokines: Functional implications on cell migration and HIV infection.
… IL-13) cytokines in the regulation of CXCR4 and CCR5 expression by monocytes, and the functional implications of Th1 and Th2 cytokine induced alterations in chemokine receptor expression on chemotaxis and HIV infection, are poorly understood and constituted the major aim of this investigation. To …
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Chemokinrezeptorexpression auf T-Zellen in bronchoalveolärer Lavage und peripherem Blut bei Kindern mit chronischer Bronchitis und interstitiellen Lungenerkrankungen
… (n=37) by flow cytometry. The percentages of CCR5+and CXCR3+ cells were determined within each T cell subset. Results are expressed as medians. For statistical analyses non-parametric tests (Wilcoxon, Mann-Whitney U) were applied. Results: In peripheral blood, the percentage of CXCR3+ T cells …
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Dynamics of HIV coreceptors and their utilization by plasma and cerebrospinal fluid HIV-1 isolates
… dynamic. In addition to the major coreceptors, CCR5 and CXCR4, several alternative coreceptors mediate entry for selected HIV isolates in vitro, although their role in vivo is yet to be established. Compartmentalized HIV-1 infection of the central nervous system (CNS) may cause neurological …
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