Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease

Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD.

Grantor dc:publisher.institution

MRC/UCT RU for Exercise and Sport Medicine

Year dc:date.issued

1998

Author dc:creator

• Coleman, Kirsty Lee

Advisor dc:contributor.advisor

• Derman, Wayne

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/17935

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/17935