{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/17935"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/17935","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease","abstract":"Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD.","abstract_html":"Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD.","abstract_has_math":false,"creators":["Coleman, Kirsty Lee"],"institution":"MRC/UCT RU for Exercise and Sport Medicine","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Derman, Wayne"],"committee_chairs":[],"committee_members":[],"year":1998,"date_issued":"1998","date_published":"1998","updated_at":"2026-07-22T22:23:01Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/17935","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Derman, Wayne"]},{"key":"dc:creator","label":"Author","values":["Coleman, Kirsty Lee"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2016-03-17T12:36:43Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2016-03-17T12:36:43Z"]},{"key":"dc:date.issued","label":"Date","values":["1998"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["MRC/UCT RU for Exercise and Sport Medicine"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/17935"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Bibliography: pages 143-154."]},{"key":"dc:description.abstract","label":"Abstract","values":["Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD."]},{"key":"dc:title","label":"Title","values":["Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease"]}]}],"canonical_facts":{"dc:contributor.advisor":["Derman, Wayne"],"dc:creator":["Coleman, Kirsty Lee"],"dc:date.accessioned":["2016-03-17T12:36:43Z"],"dc:date.available":["2016-03-17T12:36:43Z"],"dc:date.issued":["1998"],"dc:description":["Bibliography: pages 143-154."],"dc:description.abstract":["Exercise intolerance is well documented in patients with chronic obstructive pulmonary disease (COPD). Historically, this exercise intolerance has been attributed to the central factors of lung damage and subsequent heart failure. However, recent evidence suggests that (i) patients with cardiac and renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and function and their relation to exercise tolerance in patients with COPD."],"dc:identifier.uri":["http://hdl.handle.net/11427/17935"],"dc:language.iso":["eng"],"dc:publisher.department":["MRC/UCT RU for Exercise and Sport Medicine"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:01Z"}