Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Functional abnormalities"”.
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DTI-based tractographic analysis of white matter alterations in HIV infected children
… (HIV) continue to demonstrate neurodevelopmental abnormalities. Often, there is a link between structural and functional abnormalities. Previously, we found HIV-associated changes in white matter and functional networks in a cohort of 7-year-old HIV infected (HIV+) children who intiatied early …
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Exercise tolerance and skeletal muscle structure and function in patients with chronic obstructive pulminary disease
… renal failure suffer from skeletal muscle (SM) abnormalities that impair exercise tolerance and (ii) patients with chronic obstructive pulmonary disease (COPD) may have metabolic and functional abnormalities of SM. However, no studies have conducted a detailed investigation of SM structure and …
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Exercise tolerance and skeletal muscle structure and function in patients with severe chronic heart failure
… few studies describing both the structural and functional abnormalities in the skeletal muscle of patients with CHF. In the first study of this dissertation, 11 patients with end-stage heart failure (NYHA class Ill-IV) and 10 healthy control subjects (C) underwent i) graded exercise to …
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Behavior of deformed dermal fibroblasts seeded on a silicon membrane under high levels of strain
… a molecular perspective, the morphological and functional abnormalities of human dermal fibroblasts as a response to deformation produced by a normal force that can lead to the potential formation of stretch marks in pregnant women, adolescents, and people with Cushing's syndrome. The main …
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Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation
… a heart-specific PKD mouse model. Structural and functional abnormalities of cardiac tissues and fibrosis-associated pathways were analyzed.</p> <p><strong>Results:</strong> Human PKD myocardium were infiltrated by inflammatory cells M1 and M2. Expressions of transforming growth factor …
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The role of biofeedback in improving anal continence after anterior resection
… methods for measuring the structural and functional abnormalities associated with it. Symptom-score and quality of life questionnaires, anorectal physiology and proctography are frequently used to evaluate pelvic floor patients but are also relevant to assess anterior resection patients. …
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Chronic Stress Effects on Prefrontal Cortical Structure and Function
… of depression are associated with structural and functional abnormalities in the prefrontal cortex. In three parallel rodent and human neuroimaging studies, this project assessed the effects of chronic stress on prefrontal cortical structure and function and the behavioral correlates of these …
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Shear Stress-Mediated Tumor-Endothelial Cross Talk Regulates the Angiogenic Potential of Breast Tumors In Vitro
The structural and functional abnormalities of the tumor vasculature generate regions of elevated interstitial fluid pressure and aberrant flow shear stress within the tumor microenvironment. While research has shown that the hydrodynamics of the tumor vasculature reduce transport and uptake of …
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The role of myocardial fibrosis and ventricular mechanical dyssynchrony in the pathogenesis and treatment of contractile myocardial dysfunction.
Structural and functional abnormalities of the left ventricle and atrium are important prognostic factors in patients with cardiovascular disease. Dysfunction of the left ventricle in heart failure exposes the left atrium to elevated pressures during diastole, which result in adverse left atrial …
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Functional neuroimaging studies of peripheral inflammation-related depression
… may elicit depressive symptoms via brain functional abnormalities. In Chapter 2 I present a more focused discussion in the form of a literature review of current brain functional neuroimaging studies on inflammation-linked depression. I noted through this endeavor that the body of …
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Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model
… have shown macroscopic structural and functional abnormalities in the prefrontal cortex (PFC) of depressed patients. The monoamine hypothesis of depression is based on the neurotransmitter imbalance, such as deceased serotonin brain levels are implicated in the cause of depression. …
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The role of diet therapy in chronic kidney disease
… definitions and diagnosed, when structural or functional abnormalities of the kidneys persist for more than 3 months. End-stage kidney disease is the last stage of chronic kidney disease and is associated with a decreased quality of life and life expectancy. This comprehensive literature review …
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The utility of the 1994 versus the revised 2010 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Task Force diagnostic criteria for identifying mutation-positive probands with ARVC
… cardiac disorder characterised by structural and functional abnormalities of the right ventricle with or without left ventricular involvement. In 1994, Task Force criteria (TFC) were proposed for the diagnosis of ARVC and were found to be highly specific but lacked sensitivity. In 2010, revised …
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EEG Asymmetries in Survivors of Severe Motor Accidents: Association with Posttraumatic Stress Disorder and its Treatment as well as Posttraumatic Growth
… increase in the understanding of structural and functional abnormalities in PTSD could be achieved in the last decades due to neuroimaging research, there are still numerous unanswered questions. Especially, there is only little research explicitly examining activation asymmetries in PTSD. …
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Modelling the early development of cartilage and bone in Mseleni Joint Disease using induced pluripotent stem cells
… joints are the hip, and early developmental abnormalities lead to secondary osteoarthropathy. Autoradiographs show irregularities and fragmentation of the joint epiphyses in the early stage of MJD. Over time, erosion of the articular cartilage leads to fibrillation and flaking that ultimately …
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Magnetic resonance imaging studies of cardiac changes in diabetic and hypertensive rats
… for the first time, the structural and functional changes in the left and right ventricles following induction of diabetes in streptozotocin-treated rats. The effects of the angiotensin-converting enzyme inhibitor captopril upon such changes were also investigated. Finally, the MRI …
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Natural versus synthetic alpha-tocopherol using cell and animal models
… fetal-resorption is not a translatable functional endpoint for humans, and bioaccumulation data do not necessarily reflect biological activity in tissues. Our studies are linked by a common objective: To directly compare dietary natural vs. synthetic α-T using human-relevant functional …