Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells

Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection.

Grantor dc:publisher.institution

Division of Immunology

Year dc:date.issued

2012

Author dc:creator

• Darby, Matthew G

Advisors dc:contributor.advisor

• Brombacher, Frank
• Horsnell, William

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/14954

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/14954