Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"TH2 response"”.
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events evident in this disease stem from a failure to regulate the underlying immune response. How these events …
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Investigation Into Regulatory Mechanisms That Limit The Th2 Response in a Mouse Model of Allergic Asthma
… IgE arise as a consequence of a CD4<sup>+</sup> Th2 cell response in the airway following exposure to allergen. It has been proposed that the chronic inflammation and associated airway events evident in this disease stem from a failure to regulate the underlying immune response. How these events …
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A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… or IL-25, which contribute to induction of a Th2 response, were administered either during the chronic challenge period or in early life alone. Results: Development of an asthmatic phenotype (allergic airway inflammation, changes of remodelling and airway hyperresponsiveness (AHR)) required …
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Mold Induced Asthma: Not all Molds are Created Equal
… (AHR), eosinophilia, and a predominately Th2 response, while A. versicolor induced a strong Th17 response and neutrophilic inflammation, but very mild AHR. Neutralization of IL-17A resulted in strong AHR and eosinophilic inflammation following A. versicolor exposure. In Dectin-1 deficient …
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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
… But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. …
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Role of T cells and cytokines in the induction of tolerance to renal tubular antigen in active Heymann nephritis
… aims to further examine the role of T cell responses in active HN. First, the effect of the anti-CD3 monocIonal antibody (mAb) G4.18 was investigated. Anti-CD3 given 4 weeks after immunization prevented the development of proteinuria, delayed anti-RTA antibody responses, and reduced …
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The role of CD4+T cells in host protective responses against cutaneous Leishmaniasis using genome-wide transcriptomics.
… C57BL/6 “healer” mice produced a predominant TH1 response, whereas the iLCKcreIL-4Rα-/lox mice and susceptible BALB/c mice produced a TH2 response.
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Clinical and immunological factors associated with post-race upper respiratory tract symptoms (URTS) in Ironman triathletes
… analysis of cytokines representing mainly a TH1 response (IL-2, and IL-12) (cell mediated immunity) and a TH2 response (IL-4, IL-6, IL-10) (humoral immunity), as well as a saliva sample (for salivary α-amylase, cortisol and IgA concentrations). Collection of blood and saliva samples was repeated …
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Characterizing physiological and genetic differences in the early immune response to Haemonchus contortus in resistant and susceptible sheep
This dissertation compares immune responses of resistant and susceptible sheep to infection with Haemonchus contortus during the peri-parturient period and larval stage of infection. Identification of immunological events resulting in parasite resistance in St. Croix hair sheep may provide better …
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Mast cells in gastrointestinal helminth infection
Helper T cells type 2 (Th2)play an essential role in host protective responses against the gastrointestinal (GI) nematode parasite, Trichinella spiralis. It is believed that mast cell recruitment and activation may be associated with parasite expulsion from mice. In the current study, we …
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The role of IL-4Rá in Nippostrongylus brasiliensis-induced chronic lung pathology
… IL-4Rá signalling is the induction of a strong TH2 response which induces the development of alternatively activated macrophages (AAMs). AAMs are associated with tissue remodelling and the control of exacerbated inflammation. In order to investigate potential roles for IL-4Rá in N. brasiliensis' …
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Investigating the role of B and T lymphocytes in the course of murine Leishmania Major infection
… documented that T-helper 1(Th1) and T-helper 2 (Th2) responses lead to resistance and susceptiblity to L. major respectively. Recent studies have now shown that B-cells are capable to producing key T-cell differentiating cytokines such as IL-4 and IFN-γ. More specifically, two new B-cell …
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Interleukin-10 Induces Apoptosis in Developing Mast Cells via a Mitochondrial, STAT3-dependent Pathway
… in either connective tissue or mucosa. Th2 cytokines have been implicated in the regulation of mast cell development and subsequent function. Mast cells have also been shown to be essential players in many Th2 immune responses. In the following study we investigate the effects of the Th2 …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
… in hamsters is described here as a mixed Th1 and Th2 response marked by increased mRNA of associated transcription factors, cytokines and chemokines. The capacity for the CD4+ T cells from the chronically infected hamsters to activate macrophages and induce parasite killing was present but …
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The Impact of Vitamin D on the Epidemiology, Pathogenesis, and Treatment of Esophageal Adenocarcinoma
… of GERD, and factors predicting a positive response to treatment is necessary to improve outcomes. Vitamin D is a hormone that acts as an immunomodulator and regulator of cellular proliferation with anticancer properties, and has been implicated in the prevention of some cancers. Its main …
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Characterising the immune response to Salmonella and Salmonella surface antigens during a systemic infection
… work has explored the cell-mediated and humoral response to STm and its component antigens, their intrinsic properties, and capacity to act as protective immunogens in a mouse model. In particular, responses to surface exposed structures such as the outer membrane proteins (Omps) and the …
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Modeling host responses to tick feeding and tick-borne flavivirus evolution and dispersal
… mixture of salivary molecules that inhibit host responses such as coagulation, complement, itch responses, and immune responses. Ticks act as vectors for an extremely broad range of human and animal pathogens. Many tick-borne pathogens are significant public health risks throughout the world. In …
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Bacterial outer membrane vesicles (OMVs) as a platform for personalized cancer vaccines
… targets of an effective anti-cancer T cell response. Increasing evidence demonstrated that cancer vaccines targeting neoepitopes are effective and safe both in preclinical models and human patients. Bacterial Outer Membrane Vesicles (OMVs) are naturally produced by all Gram-negative …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such …
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The role of pulmonary innate and adaptive immune responses to helminth infection
… nematode infections requires a host T helper 2 (Th2) response promoted by epithelial cell driven IL-33 induction of cytokine secretion of Interleukin (IL)-4, 5 and 13 by a range of immune cells including innate lymphoid cells type 2 (ILC2s) and CD4+ T cells. This induces effector responses such …
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