{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/14954"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/14954","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells","abstract":"Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection.","abstract_html":"Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection.","abstract_has_math":false,"creators":["Darby, Matthew G"],"institution":"Division of Immunology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Brombacher, Frank","Horsnell, William"],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-22T22:23:36Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/14954","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Brombacher, Frank","Horsnell, William"]},{"key":"dc:creator","label":"Author","values":["Darby, Matthew G"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-11-13T13:03:06Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-11-13T13:03:06Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Immunology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/14954"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection."]},{"key":"dc:title","label":"Title","values":["Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells"]}]}],"canonical_facts":{"dc:contributor.advisor":["Brombacher, Frank","Horsnell, William"],"dc:creator":["Darby, Matthew G"],"dc:date.accessioned":["2015-11-13T13:03:06Z"],"dc:date.available":["2015-11-13T13:03:06Z"],"dc:date.issued":["2012"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis infection is an area of immunity that is currently not well defined. Recently, it has been shown that B-cells are essential to the resolution of a Heligomosomoides polygyrus infection, another parasitic helminth. Our aim in this study was to investigate any role that B-cells may play in response to a secondary N. brasiliensis infection by analysing the differences in immunity of wild-type and B-cell-specific IL-4Rα knockout mice after a N. brasiliensis re-infection."],"dc:identifier.uri":["http://hdl.handle.net/11427/14954"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Immunology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:23:36Z"}