Proteomic analysis of the Mycobacterium avium-containing phagosome membrane

Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival.

Grantor dc:publisher.institution

Division of Medical Biochemistry

Year dc:date.issued

2010

Author dc:creator

• Pietersen, Ray-Dean Donovan

Advisor dc:contributor.advisor

• Thilo, Lutz

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/12226

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/12226