{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/12226"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/12226","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"Proteomic analysis of the Mycobacterium avium-containing phagosome membrane","abstract":"Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival.","abstract_html":"Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival.","abstract_has_math":false,"creators":["Pietersen, Ray-Dean Donovan"],"institution":"Division of Medical Biochemistry","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Thilo, Lutz"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:22:54Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/12226","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Thilo, Lutz"]},{"key":"dc:creator","label":"Author","values":["Pietersen, Ray-Dean Donovan"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-15T11:30:09Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-15T11:30:09Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Medical Biochemistry"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MSc"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/12226"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes abstract.","Includes bibliographical references (leaves 139-158)."]},{"key":"dc:description.abstract","label":"Abstract","values":["Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival."]},{"key":"dc:title","label":"Title","values":["Proteomic analysis of the Mycobacterium avium-containing phagosome membrane"]}]}],"canonical_facts":{"dc:contributor.advisor":["Thilo, Lutz"],"dc:creator":["Pietersen, Ray-Dean Donovan"],"dc:date.accessioned":["2015-01-15T11:30:09Z"],"dc:date.available":["2015-01-15T11:30:09Z"],"dc:date.issued":["2010"],"dc:description":["Includes abstract.","Includes bibliographical references (leaves 139-158)."],"dc:description.abstract":["Pathogenic mycobacteria, like [Mycobacterium tuberculosis] M.tb and Mycobacterium avium (M.av), reside intracellularly in phagosomes where they are able to survive, because they block the process of phagosome maturation. ... An approach of characterizing M.av-containing phagosomes in terms of cell surface-derived glycoconjugates, revealed that these phagosomes show a 3- to 4-fold depletion of these glycoconjugates as compared to early endosomes with which the phagosomes continuously fuse and exchange membrane molecules... The aim of this study is to identify the depleted / possibly enriched cell surface derived glycoproteins on the phagosome membrane of M.av-containing phagosomes, because they might play a role in mycobacteria's intracellular survival."],"dc:identifier.uri":["http://hdl.handle.net/11427/12226"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Medical Biochemistry"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["Proteomic analysis of the Mycobacterium avium-containing phagosome membrane"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MSc"]},"updated_at":"2026-07-22T22:22:54Z"}