The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer

T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis.

Grantor dc:publisher.institution

Department of Human Biology

Year dc:date.issued

2009

Author dc:creator

• Davis, Emily

Advisor dc:contributor.advisor

• Prince, Sharon

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11890

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11890