{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11890"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11890","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer","abstract":"T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. 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In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis."]},{"key":"dc:title","label":"Title","values":["The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer"]}]}],"canonical_facts":{"dc:contributor.advisor":["Prince, Sharon"],"dc:creator":["Davis, Emily"],"dc:date.accessioned":["2015-01-10T06:48:15Z"],"dc:date.available":["2015-01-10T06:48:15Z"],"dc:date.issued":["2009"],"dc:description":["Includes abstract.","Includes bibliographical references (leaves 102-131)."],"dc:description.abstract":["T-box factors play crucial roles in embryogenesis and mutations in T-box factor genes have been implicated in multiple human disorders. In addition, an increasing body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic process and further reveals a novel mechanism by which it contributes to tumourigenesis."],"dc:identifier.uri":["http://hdl.handle.net/11427/11890"],"dc:language.iso":["eng"],"dc:publisher.department":["Department of Human Biology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:42Z"}