Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 110 for “"Cell cycle -- Regulation"”.
-
Cell cycle regulation during gametogenesis in budding yeast
… reproduction depends on meiosis, the specialized cell division that gives rise to gametes. During meiosis, two consecutive rounds of chromosome segregation follow one round of DNA replication to yield four haploid gametes from one diploid progenitor. In meiosis I, homologous chromosomes segregate …
-
Mitochondrial inheritance and cell cycle regulation in Saccharomyces cerevisiae
… and other organelles are coordinated with cell cycle progression in the budding yeast, Saccharomyces cerevisiae. Recent studies have revealed a checkpoint that inhibits cytokinesis when there are severe defects in mitochondrial inheritance. An established checkpoint signaling pathway, the …
-
Cell Cycle Regulation and Cancer: The Emerging Role of KIAA1143
Proper regulation of the cell cycle checkpoints is essential for ensuring the accurate progression of each phase. When abnormalities occur in the proteins governing these checkpoints, diseases such as cancer frequently arise. These checkpoints include the G1/S transition, where cancer-associated …
-
MEIS1: At the Crossroads Between Metabolic and Cell Cycle Regulation
Stem cells undergo self-renewal, maintaining themselves in an undifferentiated state while generating differentiated cells that are required for the tissue homeostasis or repair. One intriguing feature of stem cells is their maintenance in their respective hypoxic niche. Survival in this low-oxygen …
-
Cell cycle regulation of complex formation at origins of DNA replications
This suggests that the S phase cyclin, which first activates DNA replication, then acts locally at the origin to prevent pre-RC formation.
-
Mathematical modeling of pathways involved in cell cycle regulation and differentiation
Cellular processes critical to sustaining physiology, including growth, division and differentiation, are carefully governed by intricate control systems. Deregulations in these systems often result in complex diseases such as cancer. Hence, it is crucial to understand the interactions between …
-
Links Between Adhesion Signalling and Cell Cycle Regulation in Bladder Cancer Cells
… to identify new avenues for therapy. The extracellular matrix (ECM) represents a key component of the tumour microenvironment whose biochemical and mechanical characteristics contribute to all the hallmarks of cancer. However, the role of the ECM in bladder cancer is yet to be fully explored. …
-
Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia
… for the development of nearly all white blood cell types of the immune system, including B cells, granulocytes, and monocytes. Mutation of the gene encoding PU.1, SPI1 in humans and Sfpi1 in mice, is associated with AML. We hypothesized that reduced expression of PU.1 in Sfpi1BN/BNmyeloid cells …
-
Proteomic analysis of protein complexes and cell cycle regulation in <i>Trypanosoma brucei</i>
<i>Trypanosoma brucei</i> is a unicellular trypanosomatid protozoan parasite and the etiological agent of sleeping sickness in sub-Saharan Africa. The trypanosomatid order also includes the parasites <i>Trypanosoma cruzi </i>(Chagas disease) and <i>Leishmania major</i> (Leishmaniasis). Sleeping …
-
Characterization of the effects of decreased expression of ribosomal proteins on cell transformation and cell cycle regulation
Thesis (Sc. D.)--Massachusetts Institute of Technology, Division of Toxicology, 1996.
-
Analyses of the roles of the UmuDC proteins of E. coli in SOS mutagenesis and cell cycle regulation
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 1997.
-
SCF SKP2B - AND KPC1-DEPENDENT DEGRADATION OF CYCLIN-DEPENDENT KINASE INHIBITOR KRP1 AND CELL CYCLE REGULATION IN ARABIDOPSIS THALIANA
… kinase inhibitors play a key role in cell cycle regulation by inhibiting the activities of cyclin-dependent kinase/cyclin complexes. However, little is known about the role of this group of proteins in plant cell cycle regulation. To gain insight into the mechanisms by which the plant …
-
Cell Cycle Regulation by Post-Translational and Post-Transcriptional Mechanisms in an Anaerobic Extremist- the Anoxia Tolerant Turtle, Trachemys Scripta Elegans
… that the mechanisms which suppress ATP-expensive cell cycle activity, would contribute to establishing an hypometabolic state. To explore this possibility, this thesis studied the post-transcriptional and post-translational mechanisms of cell cycle arrest during anoxic stress in the freshwater …
-
Global analysis of the transcriptional regulation of Sinorhizobium meliloti cell cycle progression and study of cell cycle regulation during symbiosis with Medicago sativa
The complex [alpha]-proteobacterial cell cycle regulatory network is essential not only for faithful replication and segregation of the genome, but also to coordinate unique cellular differentiation events that have evolved as adaptations to the different lifestyles of this diverse group of …
-
The Role of CDC25A in Ultraviolet-induced Nonmelanoma Skin Tumorigenesis
Cell division cycle 25A (CDC25A) is a dual-specificity phosphatase that removes inhibitory phosphate groups from cyclin-dependent kinases, allowing cell cycle progression. Activation of cell cycle checkpoints following DNA damage can result in degradation of CDC25A, leading to cell cycle arrest. …
-
The role of the developmentally important transcription factor, TBX2, in the cell cycle and cancer
… body of evidence implicates the T-box family in cell cycle regulation and in cancer...The aim of this study was therefore to address this question by establishing TBX2 over-expression and knockdown cell culture models. The results show that TBX2 does indeed contribute directly to the oncogenic …
-
Functional investigation of the role of the retinoblastoma protein in genome stability
… is an enabling characteristic of cancerous cells. It has recently been discovered that the retinoblastoma protein (pRB), typically known for its role in cell cycle regulation, also aids in the maintenance of genome stability. Intriguingly, mutations to the pRB gene, RB1, can arise late in …
-
Taxotere suppresses breast cancer growth through inducing lincRNA-p21 expression
… This induction contributes to DNA-damage repair, cell death and cell cycle regulation. In this study, we focused on Taxotere (TXT) mediated chemotherapy of breast cancer cells and found that lincRNA-p21 is robotically induced upon TXT treatment. Secondly, we observed increased chemoresistance in …
-
Gene expression profiling in different stages of development of Arabidopsis thaliana leaftrichomes at the single cell level
Each organ of a multicellular organism is unique at the level of its tissues and cells. Furthermore, responses to environmental stimuli or developmental signals occur differentially at the single cell or tissue level. This underlines the necessity of precise investigation of the “building block of …
-
The RASSF1A Tumor Suppressor Regulates a Cascade of Oncogenic Signals That Are Restrained by G1 Checkpoint Mechanisms
… RASSF1A is reported to regulate apoptosis, cell cycle progression, and microtubule dynamics. Disruption of these processes by RASSF1A loss may disrupt cellular integrity and promote oncogenesis. I found that RASSF1A depletion elevated oncogenic signaling pathways; however, RASSF1A depletion …
Page 1 of 6