HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy

This study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later.

Grantor dc:publisher.institution

Division of Neurosurgery

Year dc:date.issued

2012

Author dc:creator

• Cross, Helen Margot

Advisor dc:contributor.advisor

• Combrinck, MI

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/11759

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/11759