{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/11759"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/11759","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy","abstract":"This study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later.","abstract_html":"This study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later.","abstract_has_math":false,"creators":["Cross, Helen Margot"],"institution":"Division of Neurosurgery","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Combrinck, MI"],"committee_chairs":[],"committee_members":[],"year":2012,"date_issued":"2012","date_published":"2012","updated_at":"2026-07-22T22:22:41Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/11759","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Combrinck, MI"]},{"key":"dc:creator","label":"Author","values":["Cross, Helen Margot"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-01-08T19:51:16Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-01-08T19:51:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2012"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Neurosurgery"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Master Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Masters"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MMed"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/11759"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references."]},{"key":"dc:description.abstract","label":"Abstract","values":["This study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later."]},{"key":"dc:title","label":"Title","values":["HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy"]}]}],"canonical_facts":{"dc:contributor.advisor":["Combrinck, MI"],"dc:creator":["Cross, Helen Margot"],"dc:date.accessioned":["2015-01-08T19:51:16Z"],"dc:date.available":["2015-01-08T19:51:16Z"],"dc:date.issued":["2012"],"dc:description":["Includes bibliographical references."],"dc:description.abstract":["This study aimed to determine whether highly active antiretroviral therapy (HAART) improved cognitive function in HIV positive people in South Africa, and whether this effect differed according to the CNS penetration-effectiveness (CPE) of the regimen used. I also investigated potential HIV-Associated Neurocognitive Disorders (HAND) biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later."],"dc:identifier.uri":["http://hdl.handle.net/11427/11759"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Neurosurgery"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy"],"dc:type":["Master Thesis"],"dc:type.qualificationlevel":["Masters"],"dc:type.qualificationname":["MMed"]},"updated_at":"2026-07-22T22:22:41Z"}