Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"neurofilament"”.
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Neurofilament light chain
… Fall-Kontroll-Studie untersuchte den Biomarker Neurofilament light chain (NfL) bei Patient*innen mit Status epilepticus. Zu den zentralen Fragestellungen gehörte der Vergleich mit neurologisch gesunden Kontrollen, die Unterscheidung zwischen verschiedenen Statusformen sowie die prognostische …
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Effects of mitochondrial dysfunction on neurofilament turnover and distribution in human neuroblastoma cells
… of proteins including α-synuclein, ubiquitin and neurofilaments (NFs). NFs, the intermediate filaments expressed in neuronal cells are responsible for the maintenance of axonal structure. Although NFs were the first proteins identified in LBs their role in PD pathogenesis has not been fully …
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Molecular mechanisms of radial axonal growth : insights from analysis of neurofilament gene-targeted mice
… the axon and the expression of proteins known as neurofilaments (NFs) within the axon. NFs are cytoskeletal proteins composed of neurofilament light (NF-L), medium (NF-M) and heavy (NF-H) subunits. It was not well understood how NF subunits mediate the radial growth of axons. To investigate, I …
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NL6, ein neuer monoklonaler Antikörper zur Analyse der O-Glycosylierung von Neurofilament Protein M
… der ein spezifische O-Glycosylierung auf Neurofilament Protein M erkennt. In der Arbeit wurde der Antikörper allgemein charakterisiert, das Epitop in der C-terminalen KSP Region von humanen NF-M identifiziert und die Expression und Verteilung der von NL6 erkannten Subpopulation von NF-M im …
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Evaluation of Neurofilament Light Chain as a Biomarker in Dogs with Structural and Idiopathic Epilepsy
… prospective cohort study is to assess the use of neurofilament light chain (NfL) as a biomarker for diagnostic and therapeutic monitoring in dogs with idiopathic and structural epilepsy. A total of 50 dogs (36 idiopathic epilepsy and 14 structural epilepsy) were enrolled to contribute a total of …
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The role of neurofilament-light polipeptide (NEFL) in the onset and progression of hepatocellular carcinoma
… Recently, it has been shown that NEFL gene (Neurofilament-light polypeptide), whose mutations are responsible of motor-neuron disease such as Charcot-Marie-Tooth disease type 2E, is also involved in some types of malignancies. However, no information about NEFL and HCC are available. Aim: Aim …
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The effects of Parkinson's disease mimetics on the proteasomal and neurofilament systems in SH-SY5Y cells
Mitochondrial impairment, glutathione depletion and oxidative stress have been implicated in the pathogenesis of Parkinson's disease, linked recently to proteasomal dysfunction. This study analyses how these factors influence the various activities of the proteasome in SH-SY5Y human neuroblastoma …
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Immunolocalization of dystrophin and neurofilament protein in muscle spindles of normal, mdx-dystrophic, and denervated mice
… with an antibody to dystrophin and with a 200 kD neurofilament protein antibody which revealed their sensory innervation. By fluorescence microscopy, intrafusal fibers in the soleus of mdx mice were deficient in dystrophin throughout their lengths, whereas their sensory nerve-terminals stained …
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Molecular Analysis of Neural Structures During Song Learning in the Zebra Finch
… structural proteins, the medium subunit of neurofilament and myelin basic protein, as being important in the formation and completion of the motor path for song production. Transcripts coding for neurofilament are not developmentally regulated within the song circuit, yet neurofilament …
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Cytoskeletal changes in SY5Y neuroblastoma cells exposed to acrylamide: an immunocytochemical study
… cytoskeletal elements, such as phosphorylated neurofilament proteins, in relationship to functional maturity of the neuron. We used SY5Y human neuroblastoma cells as an in vitro model of neurotoxicity to investigate cytoskeletal changes that may occur from the exposure of the nervous system to …
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Traumatic Brain Injury Mechanisms in the Gottingen Minipig in Response to Two Unique Input Modes
… and linear speed for predicting underlying light neurofilament disruption. For the combined-input injury device, the strongest predictor combination was Glutamine/N-acetylaspartylglutamate at 24 hours compared to baseline and angular acceleration for predicting underlying light neurofilament …
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Machine Learning Approaches for Characterizing ALS Disease Progression
… untargeted metabolomics and phosphorylated neurofilament heavy chain for a cohort of 283 individuals across 687 visits. Our results show that a PLSR model can be used to estimate disease severity, including ALSFRS-R and Vital Capacity, from metabolite concentrations. I also show that the …
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HIV-associated neurocognitive disorders biomarkers and the response to antiretroviral therapy
… biomarkers (serum neopterin, osteopontin and neurofilament H) to determine their relationship to the severity of cognitive impairment at baseline in HAART-naïve patients, and whether initial levels of these biomarkers related to the change in cognitive function a year later.
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… interest in circulating biomarkers such as serum neurofilament light chain as they are easier to obtain from patients than imaging markers and as they can be centrally computed also in multicenter trials. The thesis aim is to evaluate imaging as well as circulating biomarkers as surrogate …
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Chlorpyrifos and chlorpyrifos oxon induce neurite retraction and cytoskeletal disruption in mouse N2a cells and human neural progenitor stem cells
… within 2 h of exposure by live cell imaging. Neurofilament disruption was detected in treated cells, by indirect immunofluorescence with anti-phosphorylated neurofilament heavy chain (pNFH) monoclonal antibody SMI34, while the microtubule network was unaffected. Western blotting analysis …
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Tissue Engineering bei peripheren Nerven : dreidimensionale Fibrin/Schwann-Zellen-Matrix in Poly-Caprolacton-Konduiten zur geführten Defektüberbrückung
… dienten als Methoden: Immunhistochemie gegen Neurofilament (S200) und Cholinacetyltransferase (ChAT), Toluidinblau Färbung der Myelinscheide und retrograde Markierung der zentralen Nervenzellkerne mittels FAST BLUE. Eine erfolgreiche Regeneration über alle Segmente wurde in den …
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Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
… zum Beispiel Aktin, Tubulin, Spektrin oder Neurofilament, beeinflussen. Angesichts der grossen Distanz zwischen Wachtumskegel und Zellkörper sind lokale Möglichkeiten zur Regulation der Proteinmengen im Wachstumskegel selbst notwendig. Diese Regulationsmöglichkeiten basieren auf dem …
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A light and electron microscope investigation of the host-parasite relationship in the brains of mice with congenital toxoplasmosis.
… staining confirmed that this layer contained neurofilament protein. Interior to this layer was a much convoluted parasitophorous vacuole membrane; exterior was the host cell membrane. In most cases, synaptic plates were noted on the outer plasma membrane. In no instance were tissue cysts …
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THE ROLE OF SKELETAL MUSCLE-SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR IN RETROGRADE TRANSPORT ALONG MOTORNEURON AXONS
… of the retrogradely transported phosphorylated neurofilament-H (NF-H-P) protein at distal motorneuron axons in young (30 day old; 30d) and young-adult (120d) transgenic mice. We show significant accumulation of NF-H-P at the distal axon in 120d muscle-BDNF deficient mice, but not in 30d animals. …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… Investigated biomarkers included dopamine, BDNF, neurofilament light chain, and CD8+ lymphocyte activation (CD38+ HLADR+). Alzheimer's Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild …
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