HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity

The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity.

Grantor dc:publisher.institution

Division of Virology

Year dc:date.issued

2010

Author dc:creator

• Gumbi, Pamela

Advisor dc:contributor.advisor

• Passmore, Jo-Ann

Language dc:language.iso

eng

Handle dc:identifier.uri

http://hdl.handle.net/11427/10501

OAI identifier oai:identifier

oai:open.uct.ac.za:11427/10501