{"id":{"repo_id":"cape-town","oai_identifier":"oai:open.uct.ac.za:11427/10501"},"canonical_url":"https://search.dev.ndltd.org/etd/cape-town/oai:open.uct.ac.za:11427/10501","repository":{"repo_id":"cape-town","name":"University of Cape Town","base_url":"https://open.uct.ac.za/oai/request"},"display":{"title":"HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity","abstract":"The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity.","abstract_html":"The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity.","abstract_has_math":false,"creators":["Gumbi, Pamela"],"institution":"Division of Virology","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":["Passmore, Jo-Ann"],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010","date_published":"2010","updated_at":"2026-07-22T22:23:07Z","subjects":[],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/11427/10501","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Passmore, Jo-Ann"]},{"key":"dc:creator","label":"Author","values":["Gumbi, Pamela"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2014-12-30T06:35:01Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2014-12-30T06:35:01Z"]},{"key":"dc:date.issued","label":"Date","values":["2010"]},{"key":"dc:publisher.department","label":"Dc Publisher Department","values":["Division of Virology"]},{"key":"dc:publisher.institution","label":"Dc Publisher Institution","values":["University of Cape Town"]},{"key":"dc:type","label":"Dc Type","values":["Doctoral Thesis"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["PhD"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/11427/10501"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Includes bibliographical references (leaves 124-150)."]},{"key":"dc:description.abstract","label":"Abstract","values":["The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity."]},{"key":"dc:title","label":"Title","values":["HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity"]}]}],"canonical_facts":{"dc:contributor.advisor":["Passmore, Jo-Ann"],"dc:creator":["Gumbi, Pamela"],"dc:date.accessioned":["2014-12-30T06:35:01Z"],"dc:date.available":["2014-12-30T06:35:01Z"],"dc:date.issued":["2010"],"dc:description":["Includes bibliographical references (leaves 124-150)."],"dc:description.abstract":["The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual transmission of HIV and subsequent pathogenesis. Elucidation of the mechanisms underlying the persistent recruitment, activation and differentiation of mucosal T cells will give crucial insight into potential therapeutic targets to restore effective local immunity."],"dc:identifier.uri":["http://hdl.handle.net/11427/10501"],"dc:language.iso":["eng"],"dc:publisher.department":["Division of Virology"],"dc:publisher.institution":["University of Cape Town"],"dc:title":["HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity"],"dc:type":["Doctoral Thesis"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["PhD"]},"updated_at":"2026-07-22T22:23:07Z"}